INTERNATIONAL REVIEW OF Neurobiology VOLUME 25 Editorial Board W.Ross ADEY JULIUS AXELROD KETY SEYMOUR KEITH KILLAM Ross BALDESSARINI CONANKORNETSKY SIR ROGERBANNISTER ABELLAJTHA FLOYDBLOOM BORISLEBEDEV DANIELBOVET PAULMANDELL PHILLIPBRADLEY H UMPHRY OSMON D JOSE DELGADO RODOLFOPAOLETT~ SIR JOHN ECCLES SOLOMONSNYDER JOEL ELKES STEPHEN SZARA H. J. EYSENCK SIR JOHN VANE KJELL FUXE MARAT VARTANIAN B o HOLMSTEDT RICHARD WYATT PAULJANSSEN OLIVER ZANGWILL INTERNATIONAL REVIEW OF Neurobiology Edited by JOHN R. SMYTHIES Department of Psychiotry and The Neurosciences P rogrom University of Alobomo Medical Center Birmingham, Alabama RONALD J. BRADLEY The Neurosciences Program University of Alabama Medical Center Birmingham, Alabomo VOLUME 25 1984 ACADEMIC PRESS, INC. (Harcourt Brace Jovonovich, Publishers) Orlando San Diego Toronto Montreal San Francisco Sydney New York Tokyo London Sbo Paulo COPYRIGHT @ 1984, BY ACADEMIC PRESS, INC. ALL RIGHTS RESERVED. NO PART O F THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS,INC. Orlando, Florida 32887 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/20 Oval Road. London N W l IDX LIBWRYOF CONGRESS CATALOG CARDNUMBER: 59 - 1 3 8 2 2 I S B N 0-12-366825-5 PRINTED IN THE UNITED STATES OF AMERICA 04 05 06 01 98 1 65 4 3 2 1 CONTENTS CONTRIBUTORS ..................................................................... iX Guanethidine-Induced Destruction of Sympathetic Neurons EUGENEM. JOHNSON. JK..A N D PAMELA TOY MANNING I . Introduction I l l . Discovery of Guanethidine-Induced Sympathectomy V. Structure-Activity Relationships VI. Mechanism of Destruction of Sympa eurons ....................... 13 VIII. Assessment of the Degree of Sympathectomy Produced by Guanethicline . . . 23 IX. Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 References ............................... Dental Sensory Receptors MAKGAREI-R. BYEKS 1. Introduction Ill. IV. V. VI. VI1. Location of Sensory Nerve Endings Ultrastructure of Sensory Nerve Endings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Neural Relationship to Other Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Sensory Transduction Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References ........................ ..... 68 74 80 85 87 Cerebrospinal Fluid Proteins in Neurology A. LOWENTHAL, R. CROL