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This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract! Featuring over 1300 references, drawings, tables, photographs, and micrographs, Drug Delivery to the Lung ·outlines the history of inhaled medications in the treatment of respiratory disease ·describes aspects of respiratory structure to inhalation therapy emphasizing developmental changes ·compares existing in vitro/in vivo correlations for key aerosol modalities with lung model predictions ·discusses particle diameter measurement, particle size statistics, and aerosol test methods ·reviews the clinical effects of altering the deposition site of various classes of aerosolized drugs ·surveys the development of novel, efficient, and convenient nebulizer systems ·details breath-actuated and spacer devices constructed for children ·analyzes dry-powder and pressurized metered dose inhalers ·considers the transition from CFCs to new environmentally friendly chemical propellants ·and more! Giving the clinician an overview of factors essential to understanding drug delivery via nebulization, Drug Delivery to the Lung is a superlative reference for pulmonologists; physiologists; pharmaceutical scientists; immunologists; allergists; analytical, organic, and medicinal chemists and biochemists; chemical, genetic, and process engineers; and medical and graduate school students in these disciplines.
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ISBN: 0-8247-0541-6 This book is printed on acid-free paper. Headquarters Marcel Dekker, Inc. 270 Madison Avenue, New York, NY 10016 tel. 212-696-9000; fax: 212-685-4540 Eastern Hemisphere Distribution Marcel Dekker AG Hutgasse 4, Postfach 812, CH-4001 Basel, Switzerland tel: 41-61-261-8482; fax: 41-61-261-8896 World Wide Web http://www.dekker.com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright © 2002 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA INTRODUCTION As pointed out in the first chapter of this volume, inhalation therapy is not new! Granted, the drugs delivered to the lungs by this method, the propellants, and the methods themselves are undoubtedly new and constantly improving, but let’s admit it: the basic principles were established a thousand years ago. Asthma is certainly one of the diseases, if not the disease, that has benefited most from this therapeutic approach. In the nineteenth century, one of the “Renaissance men” in the field of asthma therapy was Henry Hyde Salter, a Fellow of the Royal College of Physicians and a physician at Charing Cross Hospital. He was a strong advocate of inhalation therapy but, at least by today’s standards, his remedies were horrifying. Indeed, one was tobacco! That may be hard to believe, but just read the following: “For tobacco to cure asthma, as a depressant, it must produce collapse; as a sedative it merely produces that confusing and tranquilizing condition with which smokers are so familiar.” And the story goes on, stating that even children may be cured with tobacco, but “in carefully measured quantities.” In his book On Asthma: Its Pathology and Treatment, Salter suggests many other remedies for the treatment of asthma. The point of all this is