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ADVANCES IN CANCER RESEARCH VOLUME 15 Contributors to This Volume L. Renato Baserga J. Ernest Borek J. Paul J. S. Butel V. S. Shapot Philip J. Fialkow Gary Stein J. H. C. Ho Harold M. Swartz Sylvia J. Kerr S. S. Tevethia A. J. MacGillivray G. Threlfall Melnick ADVANCES IN CANCER RESEARCH Edited by GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden SIDNEY WEINHOUSE Fels Research Institute Temple University Medical School Philadelphia, Pennsylvania Consulting Editor ALEXANDER HADDOW Chester Beatty Research Institute Institute of Cancer Research Royal Cancer Hospital London, England Volume 75 (29 ACADEMIC PRESS New York and London 1972 COPYRIGHT 8 1972, BY ACADEMIC PRESS, INC. ALL RIGHTS RESERVED NO PART OF THIS BOOK MAY BE REPRODUCED IN ANY FORM, BY PHOTOSTAT, MICROFILM, RETRIEVAL SYSTEM, OR ANY OTHER MEANS, WITHOUT WRl"EN PERMISSION FROM THE PUBLISHERS. ACADEMIC PRESS INC. 111 Fifth Avenue, New qork, New York 10003 United Kingdom Edition published by ACADEMIC PRESS, INC. (LONDON) LTD. 24/28 Oval Road, London NW17DD Lmmy OF CONORESS CATALOO CARDNUMBER:52-13360 PRINTED IN THE UNlTED STATES OF AMERICA CONTENTS CONTRIBUTORS TO VOLUME15 . CONTENTSOF PREVIOUS VOLUMES . . . . . . . . . . . . . . . . . . . . . . ix xi Oncogenicity and Cell Transformation by Papovavirus SV40: The Role of The Viral Genome J . S. BUTEL.S. S . TEVETHIA. AND J . L . MELNICK I. Introduction . . . . . . . . . . . . 11. Oncogenic Potential of SV40 in Vivo . . . . . . . . . 1 2 11 19 32 46 48 . . . . .