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Macrocyclic Lactones in Antiparasitic Therapy
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Macrocyclic Lactones in Antiparasitic Therapy
Edited by
J. VERCRUYSSE Faculty of Veterinary Medicine Department of Virology, Parasitology, Immunology Ghent University Belgium and
R.S. REW Pfizer Animal Health Exton Pennsylvania USA
CABI Publishing
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CABI Publishing is a division of CAB International CABI Publishing CAB International Wallingford Oxon OX10 8DE UK Tel: +44 (0)1491 832111 Fax: +44 (0)1491 833508 E-mail:
[email protected] Website: www.cabi-publishing.org
CABI Publishing 10E 40th Street Suite 3203 New York, NY 10016 USA Tel: +1 212 481 7018 Fax: +1 212 686 7993 E-mail:
[email protected]
©CAB International 2002. All rights reserved. No part of this publication may be reproduced in any form or by any means, electronically, mechanically, by photocopying, recording or otherwise, without the prior permission of the copyright owners.
A catalogue record for this book is available from the British Library, London, UK. Library of Congress Cataloging-in-Publication Data Macrocyclic lactones in antiparasitic therapy / edited by J. Vercruysse and R.S. Rew p. cm. Includes bibliographical references (p. ). ISBN 0-85199-617-5 (alk. paper) 1. Avermectins. 2. Lactones. 3. Macrocyclic compounds. 4. Antiparasitic agents. I. Vercruysse, J. (Jozef) II. Rew, Robert S. RM412 .M33 2002 616.9′6061--dc21 2002004075
ISBN 0 85199 617 5
Typeset by AMA DataSet Ltd, UK Printed and bound in the UK by Cromwell Press, Trowbridge
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Contents
Contributors Preface 1. 1.1. 1.2. 1.3. 1.4.
2.
Chemistry, Pharmacology and Safety of the Macrocyclic Lactones Ivermectin, Abamectin and Eprinomectin W. Shoop and M. Soll Doramectin and Selamectin G.A. Conder and W.J. Baker Milbemycin Oxime M. Jung, A. Saito, G. Buescher, M. Maurer and J.-F. Graf Moxidectin D.W. Rock, R.L. DeLay and M.J. Gliddon Pharmacokinetics of the Macrocyclic Lactones: Conventional Wisdom and New Paradigms D.R. Hennessy and M.R. Alvinerie
ix xiii
1 1 30 51 75
97
3.
Mode of Action of the Macrocyclic Lactones R.J. Martin, A.P. Robertson and A.J. Wolstenholme
125
4.
Ecological Impact of Macrocyclic Lactones on Dung Fauna J.W. Steel and K.G. Wardhaugh
141
5.
Resistance Against Macrocyclic Lactones R.K. Prichard
163
v
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