E-Book Overview
In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.
E-Book Content
GLUTAMATE and A DDIC T ION EDITED BY
BARBARA H. HERMAN, PhD CO-EDITED BY
JERRY FRANKENHEIM, PhD R AYE Z. LITTEN, PhD PHILIP H. SHERIDAN, MD FORREST F. WEIGHT, MD STEVEN R. ZUKIN, MD
HUMANA PRESS
GLUTAMATE AND ADDICTION
C ontemporary C linical N euroscience
Series Editors: Ralph Lydic and Helen A. Baghdoyan
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Contemporary Clinical Neuroscience
GLUTAMATE AND ADDICTION Edited by
BARBARA H. HERMAN,
PhD
Clinical Medical Branch, Division of Treatment Research and Development National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) Be