Color profile: Disabled Composite Default screen Macrocyclic Lactones in Antiparasitic Therapy 1 Z:\Customer\CABI\A4325 - Vercruysse - Macrocyclic Lactones\A4414 - Vercruysse - Vouchers #A.vp Thursday, October 31, 2002 10:12:54 AM Color profile: Disabled Composite Default screen Macrocyclic Lactones in Antiparasitic Therapy Edited by J. VERCRUYSSE Faculty of Veterinary Medicine Department of Virology, Parasitology, Immunology Ghent University Belgium and R.S. REW Pfizer Animal Health Exton Pennsylvania USA CABI Publishing 3 Z:\Customer\CABI\A4325 - Vercruysse - Macrocyclic Lactones\A4414 - Vercruysse - Vouchers #A.vp Thursday, October 31, 2002 10:12:54 AM Color profile: Disabled Composite Default screen CABI Publishing is a division of CAB International CABI Publishing CAB International Wallingford Oxon OX10 8DE UK Tel: +44 (0)1491 832111 Fax: +44 (0)1491 833508 E-mail:
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[email protected] ©CAB International 2002. All rights reserved. No part of this publication may be reproduced in any form or by any means, electronically, mechanically, by photocopying, recording or otherwise, without the prior permission of the copyright owners. A catalogue record for this book is available from the British Library, London, UK. Library of Congress Cataloging-in-Publication Data Macrocyclic lactones in antiparasitic therapy / edited by J. Vercruysse and R.S. Rew p. cm. Includes bibliographical references (p. ). ISBN 0-85199-617-5 (alk. paper) 1. Avermectins. 2. Lactones. 3. Macrocyclic compounds. 4. Antiparasitic agents. I. Vercruysse, J. (Jozef) II. Rew, Robert S. RM412 .M33 2002 616.9′6061--dc21 2002004075 ISBN 0 85199 617 5 Typeset by AMA DataSet Ltd, UK Printed and bound in the UK by Cromwell Press, Trowbridge 4 Z:\Customer\CABI\A4325 - Vercruysse - Macrocyclic Lactones\A4414 - Vercruysse - Vouchers #A.vp Thursday, October 31, 2002 10:12:55 AM Color profile: Disabled Composite Default screen Contents Contributors Preface 1. 1.1. 1.2. 1.3. 1.4. 2. Chemistry, Pharmacology and Safety of the Macrocyclic Lactones Ivermectin, Abamectin and Eprinomectin W. Shoop and M. Soll Doramectin and Selamectin G.A. Conder and W.J. Baker Milbemycin Oxime M. Jung, A. Saito, G. Buescher, M. Maurer and J.-F. Graf Moxidectin D.W. Rock, R.L. DeLay and M.J. Gliddon Pharmacokinetics of the Macrocyclic Lactones: Conventional Wisdom and New Paradigms D.R. Hennessy and M.R. Alvinerie ix xiii 1 1 30 51 75 97 3. Mode of Action of the Macrocyclic Lactones R.J. Martin, A.P. Robertson and A.J. Wolstenholme 125 4. Ecological Impact of Macrocyclic Lactones on Dung Fauna J.W. Steel and K.G. Wardhaugh 141 5. Resistance Against Macrocyclic Lactones R.K. Prichard 163 v 5 Z:\Customer\CABI\A4325 -