E-Book Overview
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis.In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
E-Book Content
The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer
Zofia Zukowska Giora Z. Feuerstein
Editors
Birkhäuser Verlag Basel · Boston · Berlin
Editors Zofia Zukowska Department of Physiology and Biophysics Georgetown University Medical Center 3900 Reservoir Rd., NW, Washington, DC 20057 USA
Giora Z. Feuerstein Wyeth Research Building A3153 500 Arcola Rd Collegeville, PA 19426 USA
Library of Congress Cataloging-in-Publication Data The NPY family of peptides in immune disorders, inflammation, angiogenesis and cancer / Zofia Zukowska, Giora Z. Feuerstein, editors. p. ; cm. -- (Progress in inflammation research) Includes bibliographical references and index. ISBN-13: 978-3-7643-7159-3 (alk. paper) ISBN-10: 3-7643-7159-5 (alk. paper) 1. Neuropeptide Y--Pathophysiology. I. Zukowska, Zofia. II. Feuerstein, Giora Z., 1946-. III. PIR (Series) QP552.N38N4767 2005 612’.015756--dc22 20050053007
Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the internet at http://dnb.ddb.de
ISBN-10: 3-7643-7159-5 Birkhäuser Verlag, Basel – Boston – Berlin ISBN-13: 978-3-7643-7159-3 Birkhäuser Verlag, Basel – Boston – Berlin The publisher and editor can give no guarantee for the information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must be obtained. © 2005 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland Part of Springer Science+Business Media Printed on acid-free paper produced from chlorine-free pulp. TCF ∞ Cover design: Markus Etterich, Basel Cover illustration: Figure from Li L, Lee EW, Ji H, Zukowska Z (2003) Neuropeptide Y-induced acceleration of postangioplasty occlusion of rat carotid artery. ATVB 23: 1204–1210; with kind permission of the publisher (LWW). Printed in Germany ISBN-10: 3-7643-7159-5 e-ISBN: 3-7643-7427-6 ISBN-13: 978-3-7643-7159-3 987654321
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Contents
List of contributors
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Zofia Zukowska a