E-Book Overview
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
E-Book Content
TRANSLATIONAL PAIN RESEARCH FROM MOUSE TO MAN
© 2010 by Taylor and Francis Group, LLC
FRONTIERS IN NEUROSCIENCE Series Editors Sidney A. Simon, Ph.D. Miguel A.L. Nicolelis, M.D., Ph.D.
Published Titles Apoptosis in Neurobiology Yusuf A. Hannun, M.D., Professor of Biomedical Research and Chairman, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina Rose-Mary Boustany, M.D., tenured Associate Professor of Pediatrics and Neurobiology, Duke University Medical Center, Durham, North Carolina Neural Prostheses for Restoration of Sensory and Motor Function John K. Chapin, Ph.D., Professor of Physiology and Pharmacology, State University of New York Health Science Center, Brooklyn, New York Karen A. Moxon, Ph.D., Assistant Professor, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania Computational Neuroscience: Realistic Modeling for Experimentalists Eric DeSchutter, M.D., Ph.D., Professor, Department of Medicine, University of Antwerp, Antwerp, Belgium Methods in Pain Research Lawrence Kruger, Ph.D., Professor of Neurobiology (Emeritus), UCLA School of Medicine and Brain Research Institute, Los Angeles, California Motor Neurobiology of the Spinal Cord Timothy C. Cope, Ph.D., Professor of Physiology, Wright State University, Dayton, Ohio Nicotinic Receptors in the Nervous System Edward D. Levin, Ph.D., Associate Professor, Department of Psychiatry and Pharmacology and Molecular Cancer Biology and Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina Methods in Genomic Neuroscience Helmin R. Chin, Ph.D., Genetics Research Branch, NIMH, NIH, Bethesda, Maryland Steven O. Moldin, Ph.D., University of Southern California, Washington, D.C. Methods in Chemosensory Research Sidney A. Simon, Ph.D., Professor of Neurobiology, Biomedical Engineering, and Anesthesiology, Duke University, Durham, North Carolina Miguel A.L. Nicolelis, M.D., Ph.D., Professor of Neurobiology and Biomedical Engineering, Duke University, Durham, North Carolina The Somatosensory System: Deciphering the Brain’s Own Body Image Randall J. Nelson, Ph.D., Professor of Anatomy and Neurobiology, University of Tennessee Health Sciences