Analytical Profiles of Drug Substances Volume 16 Edited by Klaus Florey The Squibb Institute for Medical Research New Brunswick, New Jersey Contributing Editors Abdullah A. Al-Badr Gerald S. Brenner 1987 ACADEMIC PRESS, INC. Harcourt Brace Jovanovich, Publishers Orlando San Diego New York Ailstin Boston London Sydney Tokyo Toronto EDITORIAL BOARD Abdullah A. Al-Badr Steven A. Benezra Gerald S. Brenner Glenn A. Brewer, Jr. Nicholas DeAngelis Lee T. Grady Eugene Inman Joseph Mollica Milton D. Yudis John Zarembo Academic Press Rapid Manuscript Reproduction COPYRIGHT 0 1987 BY ACADEMIC PRESS. INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY B E REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS, INC. Orlando, Florida 32887 United Kingdom Edition published by ACADEMIC PRESS INC. (LONDON) LTD. 24-28 Oval Road, London NW I 7DX Library of Congress Cataloging in Publication Data (Revised for volume 16) Analytical profiles o f drug substances. Compiled under the auspices o f the Pharmaceutical Analysis and Control Section, Academy of Pharmaceutical Sciences. Includes bibliographical references and indexes. 1. Drugs-Analysis-Collected works. 2. Chemistry, Pharmaceutical-Collected works. I. Florey, Klaus, 11. Brewer, Glenn A. 111. Academy of Pharmaceutical Sciences. Pharmaceutical Analysis Control Section. [DNLM: 1. Drugs-Analysis-Yearbooks. QV740 A A 1 ASS] RS 189.A58 6 lSI.1 70-187259 ISBN 0-12-260816-X (v. 16 : alk. paper) PRINTED IN THE UNITED STATES OF AMERICA 8 7 888990 9 8 7 6 5 4 3 2 1 AFFILIATIONS OF EDITORS AND CONTRIBUTORS Mohammad A . Abounassif, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Abdul Fattah A . Afify, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Abdullah A . Al-Budr, King Saud University, Riyadh, Saudi Arabia Mohammed A . Al-Yahya, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Salim A . Babhair, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Jos H . Beijnen, Slotervaart Hospital, Amsterdam, The Netherlands Steven A . Benezra, Wellcome Research Laboratories, Research Triangle Park, North Carolina Gerald S. Brenner, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania Glenn A . Brewer, Jr., The Squibb Institute for Medical Research, New Brunswick, New Jersey Auke Bult, Faculty of Pharmacy, State University of Utrecht, Utrecht, The Netherlands Nicholas J. DeAngelis, Wyeth Laboratories, Philadelphia, Pennsylvania Humeida A. El-Obeid, King Saud University, Riyadh, Saudi Arabia Klaus Florey, The Squibb Institute for Medical Research, New Brunswick, New Jersey Dennis K . G . Gorecki, College of Pharmacy, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Lee T . Grady, The United States Pharmacopeia, Rockville, Maryland Mahmoud M . A . Hassan, King Saud University, Riyadh, Saudi Arabia Eugene L. Inman, Lilly Research Laboratories, Indianapolis, Indiana vii ... Vlll AFFILIATIONS Dominic P . I p , Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania Casimir A . Janicki, McNeil Pharmaceutical, Spring House, Pennsylvania Vijay K . Kapoor, Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India Alice E . Loper, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania David J . Mazzo, Travenol Laboratories, Morton Grove, Illinois A . G. Mekkawi, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia Joseph A . Mollica, Pharmaceuticals, Du Pont, Wilmington, Delaware Jaber S. Mossa, College of Pharmacy, King Saud