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Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screening techniques and molecular targets proliferate, natural products are once again taking a central part of modern pharmaceutical research. Anticancer Agents from Natural Products analyzes current clinically-used anticancer agents that are natural products or clearly derived from natural product leads. This multi-authored volume provides a historical, biochemical, and chemical rationale to the search for plant, marine, or microbial sources that may provide future templates for drug lead optimization and synthetic drug design. Grouped by source organism, each chapter includes the history of the drug and a discussion of its mechanism in action, medicinal chemistry, and biochemistry. The authors characterize each compound by its structure, genetics, molecular biology, synthesis, and possible derivatives. They also discuss \approaches to drug discovery and development, including the use of combinatorial biosynthetic techniques, testing methods, and ways to obtain economically viable amounts of the drug. The final chapter covers drug candidates that are in preclinical or clinical development and may be used in the future.Edited by leading scientists who have contributed enormously to natural product development and potential anticancer natural products, Anticancer Agents from Natural Products is a convenient summary of the current status of research and development of some of the most effective anticancer agents available today. It is an ideal foundation for scientists engaged in developing new and improved drugs based on natural sources.
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ANTICANCER AGENTS from NATURAL PRODUCTS Edited by Gordon M. Cragg David G.I. Kingston David J. Newman Boca Raton London New York Singapore A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc. Copyright © 2005 CRC Press, LLC 1863_Discl.fm Page 1 Thursday, May 12, 2005 10:43 AM Published in 2005 by CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2005 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8493-1863-7 (Hardcover) International Standard Book Number-13: 978-0-8493-1863-4 (Hardcover) Library of Congress Card Number 2004065568 This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC) 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variet