Drug Delivery Research Advances

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Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might be susceptible to degradation or are not incorporated efficiently. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunisations are based on the delivery of protein drugs and are often done by injection.Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. This new book focuses on worldwide research on drug delivery and targeting at the molecular, cellular, and higher levels.

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DRUG DELIVERY RESEARCH ADVANCES DRUG DELIVERY RESEARCH ADVANCES BORIS O. MASHKEVICH EDITOR Nova Science Publishers, Inc. New York Copyright © 2007 by Nova Science Publishers, Inc. All rights reserved. No part of this book may be reproduced, stored in a retrieval system or transmitted in any form or by any means: electronic, electrostatic, magnetic, tape, mechanical photocopying, recording or otherwise without the written permission of the Publisher. For permission to use material from this book please contact us: Telephone 631-231-7269; Fax 631-231-8175 Web Site: http://www.novapublishers.com NOTICE TO THE READER The Publisher has taken reasonable care in the preparation of this book, but makes no expressed or implied warranty of any kind and assumes no responsibility for any errors or omissions. No liability is assumed for incidental or consequential damages in connection with or arising out of information contained in this book. The Publisher shall not be liable for any special, consequential, or exemplary damages resulting, in whole or in part, from the readers’ use of, or reliance upon, this material. Independent verification should be sought for any data, advice or recommendations contained in this book. In addition, no responsibility is assumed by the publisher for any injury and/or damage to persons or property arising from any methods, products, instructions, ideas or otherwise contained in this publication. This publication is designed to provide accurate and authoritative information with regard to the subject matter cover herein. It is sold with the clear understanding that the Publisher is not engaged in rendering legal or any other professional services. If legal, medical or any other expert assistance is required, the services of a competent person should be sought. FROM A DECLARATION OF PARTICIPANTS JOINTLY ADOPTED BY A COMMITTEE OF THE AMERICAN BAR ASSOCIATION AND A COMMITTEE OF PUBLISHERS. Library of Congress Cataloging-in-Publication Data Drug delivery research advances / Boris O. Mashkevich, editor. p. ; cm Includes bibliographical references and index. ISBN 13: 978-1-60692-602-4 1. Drug Delivery Systems. I. Mashkevich, Boris O. [DNLM: 1. Drug Delivery Systems. 2. Dosage Forms. 3. Drug Administration Routes. WB 340 D7942 2007] RS199.5.D72 2007 615’6--dc22 2007026865 Published by Nova Science Publishers, Inc. New York CONTENTS Preface vii Chapter 1 Advancements in Ocular Drug Delivery Viral Kansara, Balasubrahmanyam Budda and Ashim K. Mitra Chapter 2 Core-Shell Polymer Nanoparticle Formulations for the Oral Administration of Peptides and Proteins Irene Bravo-Osuna, Christine Vauthier and Gilles Ponchel 39 Excipients as Modulators of Drug-Carrier Mediated
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