Stem Cell Factor

Download

E-Book Overview

Stem cell factor (SCF) and its receptor, c-Kit, are essential for hematopoietic, melanocyte, and germ cell development. In the hematopoietic compartment. SCF has been shown to act on cells at multiple stages of development, including effects on primitive stem cells and their more differentiated progeny. In particular. SCF can function to promote stem/progenitor cell survival, proliferation and differentiation (especially in combination with other growth factors), adhesion, activation, and migration, chemoattraction. While c-Kit is highly expressed on differentiated mast cells and SCF is a potent mast cell growth factor. c-Kit expression is down regulated during the maturation of all other hematopoietic lineages. SCF can exist in both soluble and membrane forms which may have distinct biological functions in vivo. Further understanding of this important hematopoietic regulator will provide important insights into the biology, biochemistry, and molecular biology of hematopoetic stem cells.

E-Book Content

Stem Cell Factor Jonathan Roy Keller1,* and Diana Marie Linnekin2 1 Intramural Research and Support Program-SAIC, Frederick Cancer Research and Development Center-NCI, Building 560, Room 12-03, PO Box B, Frederick, MD 21702-1201, USA 2 Basic Research Laboratory-DBS, Frederick Cancer Research and Development Center-NCI, Building 567, PO Box B, Frederick, MD 21702-1201, USA * corresponding author tel: 301-846-1461, fax: 301-846-6646, e-mail: [email protected] DOI: 10.1006/rwcy.2000.09003. SUMMARY Stem cell factor (SCF) and its receptor, c-Kit, are essential for hematopoietic, melanocyte, and germ cell development. In the hematopoietic compartment, SCF has been shown to act on cells at multiple stages of development, including ef
You might also like

Comprehensive Clinical Psychology
Authors: Bellack A.S. , Hersen M. (eds.)    185    0

Biomedical Application Of Proteomics
Authors: Jean-Charles Sanchez , Garry L. Corthals , Denis F. Hochstrasser    137    0

Encyclopedia Of Psychotherapy
Authors: Hersen M. , Sledge W. (ed.)    181    0

Handbook Of Biomedical Image Analysis
Authors: David Wilson , Swamy Laxminarayan    206    0

Statistical Modeling For Biomedical Researchers
Authors: William D. Dupont    149    0

Information Technologies In Medicine
Authors: Akay    187    0

Abc Of Resuscitation
Authors: Michael Colquhoun , Anthony Handley , T. R. Evans    158    0

Stem Cell Factor
Authors: Johan Lennartsson    230    0

The Gale Encyclopedia Of Alternative Medicine
Authors: Jacqueline L. Longe    179    0

The Gale Encyclopedia Of Alternative Medicine
Authors: Jacqueline L. Longe    154    0