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In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate affects such addictions and how modifying certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states.
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GLUTAMATE and A DDIC T ION EDITED BY BARBARA H. HERMAN, PhD CO-EDITED BY JERRY FRANKENHEIM, PhD R AYE Z. LITTEN, PhD PHILIP H. SHERIDAN, MD FORREST F. WEIGHT, MD STEVEN R. ZUKIN, MD HUMANA PRESS GLUTAMATE AND ADDICTION C ontemporary C linical N euroscience Series Editors: Ralph Lydic and Helen A. Baghdoyan Genetics and Genomics of Neurobehavioral Disorders, edited by Gene S. Fisch, 2003 Sedation and Analgesia for Diagnostic and Therapeutic Procedures, edited by Shobha Malviya, Norah N. Naughton, and Kevin K. Tremper, 2003 Neural Mechanisms of Anesthesia, edited by Joseph F. Antognini, Earl E. Carstens, and Douglas E. Raines, 2002 Glutamate and Addiction edited by Barbara Herman, 2002 Molecular Mechanisms of Neurodegenerative Diseases edited by Marie-Françoise Chesselet, 2000 Contemporary Clinical Neuroscience GLUTAMATE AND ADDICTION Edited by BARBARA H. HERMAN, PhD Clinical Medical Branch, Division of Treatment Research and Development National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) Be