Antifungal Therapy

Antifungal Therapy Antifungal Therapy Edited by Mahmoud A. Ghannoum University Hospitals Case Medical Center Case Western Reserve University Cleveland, Ohio, USA John R. Perfect Duke University Medical Center Durham, North Carolina, USA Informa Healthcare USA, Inc. 52 Vanderbilt Avenue New York, NY 10017  C 2010 by Informa Healthcare USA, Inc. Informa Healthcare is an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8493-8787-6 (Hardcover) International Standard Book Number-13: 978-0-8493-8787-6 (Hardcover) This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequence of their use. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC) 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Antifungal therapy / edited by Mahmoud A. Ghannoum, John R. Perfect. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-0-8493-8787-6 (hardcover : alk. paper) ISBN-10: 0-8493-8787-6 (hardcover : alk. paper) 1. Antifungal agents. 2. Mycoses–Treatment. I. Ghannoum, Mahmoud A. (Mahmoud Afif) II. Perfect, John R., 1949– [DNLM: 1. Mycoses–drug therapy. 2. Antifungal Agents–therapeutic use. WC 450 A6297 2009] RM410.A58 2009 615 .792–dc22 2009036677 For Corporate Sales and Reprint Permission call 212-520-2700 or write to: Sales Department, 52 Vanderbilt Avenue, 7th floor, New York, NY 10017. Visit the Informa Web site at www.informa.com and the Informa Healthcare Web site at www.informahealthcare.com Preface This book is designed to provide a comprehensive but insightful examination of antifungal therapy in the changing clinic millenium of modern medicine. It is clear that as medicine advances to treat and cure severe underlying diseases, the collateral consequences of this management can be immunosuppression and opportunistic fungal infections. Furthermore, there are a series of primary fungal infections such as dermatophytosis and endemic mycoses which continue to plague normal hosts. Furtherm