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This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of researchers, specialists and practitioners in the field Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review Supported by a dedicated website at www.blackwellpublishing.com/pelengaris An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field
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The Molecular Biology of Cancer Dedication We would like to dedicate this work to our parents, whose support and encouragement throughout our lives, education, and subsequent career development has been a major factor in our success and peace of mind. We know that Stella’s father, Andrew, who we recently lost to us, would be especially proud of this. We also thank our daughter, Charlotte, for always loving us and helping us to maintain a balance between work and private life and for being a constant reminder of the joy that family life can bring. Mike Khan and Stella Pelengaris ii The Molecular Biology of Cancer Edited by Stella Pelengaris and Michael Khan University of Warwick With contributions from Maria Blasco, Centro Nacional de Biotecnologia Norbert C.J. de Wit, University of Warwick Martine Roussel, St Jude Children’s Research Hospital Nicky Rudd, University Hospitals of Leicester and LOROS Hospice Christiana Ruhrberg, University College of London David Shima, Cancer Research UK William Steward, University of Leicester Charles Streuli, University of Manchester Anne Thomas, University of Leicester Esther Waterhouse, University Hospitals of Leicester and LOROS Hospice Cassian Yee, Fred Hutchinson Cancer Research Centre Blackwell Publishing © 2006 by Stella Pelengaris, Michael Khan, William Steward, Maria Blasco, Cassian Yee, David Shima, Charles Streuli, Norbert C.J. de Wit, Nicky Rudd, Christiana Ruhrberg, Anne Thomas, Esther Waterhouse, and Martine Roussel BLACKWELL PUBLISHING 350 Main Street, Malden, MA 02148-5020, USA 9600 Garsington Road, Oxford OX4 2DQ, UK 550 Swanston Street, Carlton, Victoria 3053, Australia The right of Stella Pelengaris and Michael Khan to be identified as the Authors of the Editorial Material in this Work has been asserted in accordance with the UK Copyright, Designs, and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs, and Patents Act 1988, without the prior permission of the publisher. First published 2006 by Blackwell Publishing Ltd 1 2006 Library of Congress Cataloging-in-Publication Data The molecular biology of cancer/edited by Stella Pelengaris and Michael Khan; contributors, Maria Blasco . . . [et al.]. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-1-4051-1814-9 (pbk. : alk. paper) ISBN-10: 1-4051-1814-8 (pbk. : alk. paper) 1. Cancer–Molecular aspects. [DNLM: 1. Neoplasms–genetics. 2. Molecular Biology. QZ 202 M7182 2006] I. Pelengaris, Stella. II.