HANDBOOK OF ISOLATION AND CHARACTERIZATION OF IMPURITIES IN PHARMACEUTICALS
This is Volume 5 of SEPARATION SCIENCE AND TECHNOLOGY A reference series edited by Satinder Ahuja
HANDBOOK OF ISOLATION AND CHARACTERIZATION OF IMPURITIES IN PHARMACEUTICALS Edited by
Satinder Ahuja Ahuja Consulting Calabash, NC
Karen Mills Alsante Pfizer, Inc. Groton, CT
Amsterdam Boston London New York Oxford San Francisco Singapore Sydney Tokyo
Paris
San Diego
Academic Press An imprint of Elsevier Science 525 B Street, Suite 1900 San Diego, California 92101-4495
ß 2003 Elsevier Science (USA) All rights reserved. This work is protected under copyright by Elsevier Science, and the following terms and conditions apply to its use: Photocopying Single photocopies of single chapters may be made for personal use as allowed by national copyright laws. Permission of the Publisher and payment of a fee is required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms of document delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use. Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail:
[email protected] com. You may also complete your request on-line via the Elsevier Science homepage (http://www.elsevier.com), by selecting ‘Customer Support’ and then ‘Obtaining Permissions’. In the USA, users may clear permissions and make payments through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA; phone: (+1) (978) 7508400, fax: (+1) (978) 7504744, and in the UK through the Copyright Licensing Agency Rapid Clearance Service (CLARCS), 90 Tottenham Court Road, London W1P 0LP, UK; phone: (+44) 207 631 5555; fax: (+44) 207 631 5500. Other countries may have a local reprographic rights agency for payments. Derivative Works Tables of contents may be reproduced for internal circulation, but permission of Elsevier Scie