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ADVANCESINCANCERRESEARCH VOLUME 49
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ADVANCES IN CANCER RESEARCH Edited by
GEORGE KLElN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden
SIDNEY WE INHOUSE Fels Research Institute Temple University Medical School Philadelphia, Pennsylvania
Volume 49- 1987
ACADEMIC PRESS, INC. Harcourt Brace Jovanovich, Publishers
Orlando San Diego New York Austin Boston London Sydney Tokyo Toronto
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CONTENTS
Interaction of Retroviral Oncogenes with the Differentiation Program of Myogenic Cells STEFAN0 ALEMA AND FRANCO TAT^
I. I1. 111. IV. V.
VI .
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Myogenic Differentiation ........................................ Properties of Avian Retroviral Oncogenes and Their Products ......... Effects of Retroviral Oncogenes on Myogenesis in Vitro . . . . . . . . . . . . . . Direct and Indirect Mechanisms Involved in the Block of Differentiation ................................................. Conclusions ...................... :............................ References ....................................................
16 22 25
The fos Oncogene INDER M . VERMAAND W. ROBERT GRAHAM I . Introduction .................................................. I1. Biology and Pathology of the FBJ Virus .......................... 111. Characterization of the FBJ Viral Complex ........................ IV . Structure of the fos Gene and Protein ............................ V. Transformation by fos Gene .................................... VI . Protooncogene fos Expression ................................... VII . Transcription of the Protooncogene fos ........................... VIII . Regulation offos Expression .................................... IX . Future Prospects .............................................. References ...................................................
29 30 32 33 37 41 47 48 49 50
Role of the abl Oncogene in Chronic Myelogenous Leukemia ANNE-MARIE MES-MASSON AND OWENN . W I ~ E I . Introduction
................................................... ............................. 111. Molecular Characterization of P210c-nbl............................. IV. Future Directions ............................................... References .................................................... I1. Structure and Expression of abl Genes
53 55 58 63 71
CONTENTS
The Epstein-Barr Virus and the Immune System
I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
11. The Virus . . . . . . . . . . 111. The EBV Receptor . . IV. B Cell .Activation by
v.
.............
............. .................. ..................
Primary EBV Infecti Cellular Immunity during Acute EBV-Induced Infectious Mononucleosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... VII. Chronic A