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ADVANCESINCANCERRESEARCH VOLUME 49 This Page Intentionally Left Blank ADVANCES IN CANCER RESEARCH Edited by GEORGE KLElN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden SIDNEY WE INHOUSE Fels Research Institute Temple University Medical School Philadelphia, Pennsylvania Volume 49- 1987 ACADEMIC PRESS, INC. Harcourt Brace Jovanovich, Publishers Orlando San Diego New York Austin Boston London Sydney Tokyo Toronto COPYRIGHT k 1987 BY ACADEVKPRESS IhC ALL RIGHTS RESLR\ kD 90 PART Of- THIS PL BLICAI IOh MAY BE RtPRODlCED OR TRANSMlTTtD Ih, A h \ FORM OR BI A h Y M F A h S FLECTRONIC OR MFCHANICZI INCI LDING PHOTOCOPY RECORDING OR \\Y IkFORMATIOh STOR4GE 4 h D RETRIEVAL SYSTEV WITHOL PtRMIFSlOh lh URlTlNG FROM THE. P l BLlSHtR 4CADEMIC PRESS. INC O i l ~ n d ~f i londe 328x7 Llnitrd Kingdom Etlifion pitblislird bx ACADEMIC PRESS INC. ( L O N D O N ) LTD 24-28 Oval Road. London NWl 7DX I IBRAR\ OF C O ~ G R EC-~TALOG SS CARDNCMBER 52-13360 ISBN 0-12-006649-1 (alk. paper) PRINTED Ih THE LhlTED SrATES Or AHERICA 87 88 89 YO 9 8 7 6 I, 4 3 2 I r CONTENTS Interaction of Retroviral Oncogenes with the Differentiation Program of Myogenic Cells STEFAN0 ALEMA AND FRANCO TAT^ I. I1. 111. IV. V. VI . Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Myogenic Differentiation ........................................ Properties of Avian Retroviral Oncogenes and Their Products ......... Effects of Retroviral Oncogenes on Myogenesis in Vitro . . . . . . . . . . . . . . Direct and Indirect Mechanisms Involved in the Block of Differentiation ................................................. Conclusions ...................... :............................ References .................................................... 16 22 25 The fos Oncogene INDER M . VERMAAND W. ROBERT GRAHAM I . Introduction .................................................. I1. Biology and Pathology of the FBJ Virus .......................... 111. Characterization of the FBJ Viral Complex ........................ IV . Structure of the fos Gene and Protein ............................ V. Transformation by fos Gene .................................... VI . Protooncogene fos Expression ................................... VII . Transcription of the Protooncogene fos ........................... VIII . Regulation offos Expression .................................... IX . Future Prospects .............................................. References ................................................... 29 30 32 33 37 41 47 48 49 50 Role of the abl Oncogene in Chronic Myelogenous Leukemia ANNE-MARIE MES-MASSON AND OWENN . W I ~ E I . Introduction ................................................... ............................. 111. Molecular Characterization of P210c-nbl............................. IV. Future Directions ............................................... References .................................................... I1. Structure and Expression of abl Genes 53 55 58 63 71 CONTENTS The Epstein-Barr Virus and the Immune System I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11. The Virus . . . . . . . . . . 111. The EBV Receptor . . IV. B Cell .Activation by v. ............. ............. .................. .................. Primary EBV Infecti Cellular Immunity during Acute EBV-Induced Infectious Mononucleosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... VII. Chronic A