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Volume 61 of "Advances in Cancer Research" includes coverage of the following: molecular approaches to cancer therapy, radiation resistance, cancer prevention research trials, mammalian gene amplification, retinoblastoma gene function, molecular genetic basis of breast cancer, and tumour promotion by okadaic acid class compounds.
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ADVANCES IN CANCER RESEARCH VOLUME 61
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ADVANCES IN CANCERRESEARCH Edited by
GEORGE F. VANDE WOUDE ABL-Basic Research Program NCI-Frederick Cancer Research and Development Center Frederick, Maryland
GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden
Volume 61
ACADEMIC PRESS, INC. Harcourt Brace EL Company
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Copyright 0 1993 by ACADEMIC PRESS,INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher.
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International Standard Serial Number: 0065-230X International Standard Book Number: 0- 12-006661-0
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CONTENTS
CONTRIBUTORS TO VOLUME 61 . . . . . . . . . . . .
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Cancer Prevention Research Trials PETER G R E E N W A L D ,
WINFRED F. M A L O N E , HARRIET R. S T E R N
MARY
E.
CERNY,
AND
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I . Introduction . . . . . . . . . . . . . . . . . . .
11. Basic Research Stiidies: Surveying earch ..................... 111. ’The Research Strategy: Froin Basic Research to Huinan Applications ............................... ....... IV. Progress i i i CIinirdl Trials . . . . ................................. .............. ........ V. C:onclusions . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . ..................................
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7 I:!
‘Lo 21
Molecular Genetic Changes in Human Breast Cancer MARCJ.VAN I. Introduction
DE Vl.JVER
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I l l . Genetic Changes in Hum;in Breast (hnc ........................ I V. Genetic Predisposition t o Breast Ca~icer. . . . . . . . . . . . . . .
V. (:onclutling Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... ............. References . . . . . . . . . . .
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CONTENTS
Molecular Approaches to Cancer Therapy
MARKA. ISRAEL 1. I l i t rod uct ion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11. Cancer as a Molecular Disorder ...........................
I l l . Molecular Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IV. Molecular Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Regulation and Mechanism of Mammalian Gene Amplification GEORGER. STARK Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Regulation of Amplitication ........ Primary Mechanisnis o