Evolutionary Methods in Biotechnology
Edited by Susanne Brakmann and Andreas Schwienhorst
Further Titles of Interest
G. Kahl The Dictionary of Gene Technology 3rd edition 2004, ISBN 3-527-30765-6
A.S. Bommarius, B.R. Riebel Biocatalysis – Fundamentals and Applications 2004, ISBN 3-527-30344-8
T. Dingermann, D. Steinhilber, G. Folkers (eds.) Molecular Biology in Medicinal Chemistry 2003, ISBN 3-527-30431-2
S. Brakmann, K. Johnsson (eds.) Directed Molecular Evolution of Proteins 2002, ISBN 3-527-30423-1
V. Braun, F. Götz (eds.) Microbial Fundamentals of Biotechnology 2001, ISBN 3-527-30615-3
Evolutionary Methods in Biotechnology Clever Tricks for Directed Evolution Edited by Susanne Brakmann and Andreas Schwienhorst
Dr. Susanne Brakmann Institut für Zoologie Angewandte Molekulare Evolution Universität Leipzig Liebigstr. 18 04103 Leipzig, Germany
[email protected] Dr. Andreas Schwienhorst Institut für Mikrobiologie und Genetik Universität Göttingen Grisebachstr. 8 37077 Göttingen, Germany
[email protected]
This book was carefully produced. Nevertheless, authors, editors and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.
Library of Congress Card No. applied for. British Library Cataloguing-in-Publication Data: A catalogue record for this book is available from the British Library Die Deutsche Bibliothek – CIP Cataloguing-in-Publication-Data: A catalogue record for this publication is available from Die Deutsche Bibliothek ISBN 3-527-30799-0 c 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Printed on acid-free paper All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law. Composition: EDV-Beratung Frank Herweg, Leutershausen Printing: betz-druck gmbh, Darmstadt Bookbinding: J. Schäffer GmbH & Co. KG, Grünstadt