E-Book Overview
A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
E-Book Content
M E T H O D S I N M O L E C U L A R M E D I C I N E TM
Myeloid Leukemia Methods and Protocols Edited by
Harry Iland Mark Hertzberg Paula Marlton
Myeloid Leukemia
M E T H O D S I N M O L E C U L A R M E D I C I N E™
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