E-Book Overview
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.Content: Chapter 1 Pharmacogenetics: A Historical Perspective (pages 1–12): Ann K. Daly Chapter 2 Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes (pages 13–80): Vita Dolzan Chapter 3 Pharmacogenetics of Phase II Drug Metabolizing Enzymes (pages 81–100): Ingolf Cascorbi Chapter 4 Pharmacogenetics of Drug Transporters (pages 101–148): Henriette E. Meyer zu Schwabedissen, Markus Grube and Heyo K. Kroemer Chapter 5 Pharmacogenetics of Drug Targets (pages 149–182): Ann K. Daly and Maria Arranz Chapter 6 Cardiovascular Pharmacogenetics (pages 183–213): Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel and Anke?Hilse Maitland?van der Zee Chapter 7 Pharmacogenetics in Psychiatry (pages 215–250): Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison and Ann K. Daly Chapter 8 Pharmacogenetics in Cancer (pages 251–270): Sharon Marsh Chapter 9 Pharmacogenetics of Asthma and COPD (pages 271–294): Ellen S. Koster, Jan A. M. Raaijmakers, Anke?Hilse Maitland?van der Zee and Gerard H. Koppelman Chapter 10 Pharmacogenetics of Adverse Drug Reactions (pages 295–321): Ann K. Daly, Martin Armstrong and Munir Pirmohamed Chapter 11 Pharmacogenomics of Inflammatory Bowel Diseases (pages 323–351): Alexander Teml, Susanne Karner, Elke Schaeffeler and Matthias Schwab Chapter 12 Pharmacogenetics of Pain Medication (pages 353–374): Jorn Lotsch Chapter 13 Ethical and Social Issues in Pharmacogenomics Testing (pages 375–400): Susanne Vijverberg, Toine Pieters and Martina Cornel Chapter 14 High?Throughput Genotyping Technologies for Pharmacogenetics (pages 401–414): Beatriz Sobrino and Angel Carracedo Chapter 15 Developments in Analyses in Pharmacogenetic Datasets (pages 415–435): Alison A. Motsinger?Reif Chapter 16 Applications of Pharmacogenetics in Pharmaceutical Research and Development (pages 437–460): Daniel K. Burns and Scott S. Sundseth Chapter 17 Role of Pharmacogenetics in Registration Processes (pages 461–475): Myong?Jin Kim, Issam Zineh, Shiew?Mei Huang and Lawrence J. Lesko Chapter 18 Pharmacogenetics: Possibilities and Pitfalls (pages 477–483): Anke?hilse Maitland?van der Zee and Ann K. Daly
E-Book Content
PHARMACOGENETICS AND INDIVIDUALIZED THERAPY
PHARMACOGENETICS AND INDIVIDUALIZED THERAPY Edited by
Anke-Hilse Maitland-van der Zee Utrecht University Utrecht, The Netherlands
Ann K. Daly Newcastle University, Newcastle upon Tyne, UK
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