Comprehensive Natural Products Ii: Chemistry And Biology: Modern Methods In Natural Products Chemistry
E-Book Overview
This work presents a definitive interpretation of the current status of and future trends in natural products-a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999).* Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine * Stimulates new ideas among the established natural products research community-which includes chemists, biochemists, biologists, botanists, and pharmacologists * Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats
E-Book Information
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Volume Info: Volume 9
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Year: 2,010
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Edition: 1
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Pages: 771
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Pages In File: 771
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Language: English
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Issue: до 2011-08
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Identifier: 0080453813,9780080453811
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Org File Size: 32,441,884
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Extension: pdf
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Toc: 1 CONAP_Contents_all_volumes......Page 1 Overview and Introduction......Page 13 Introduction......Page 16 High-Performance Reversed-Phase Chromatography......Page 19 High-Performance Normal-Phase Chromatography......Page 20 High-Performance Hydrophilic Interaction Chromatography......Page 21 High-Performance Size Exclusion Chromatography......Page 22 Summary......Page 23 Development of Analytical Method......Page 24 Scaling Up to Preparative Chromatography......Page 30 Multidimensional High-Performance Liquid Chromatography......Page 31 Purification of Natural Products by MD-HPLC Methods......Page 32 Operational Strategies for MD-HPLC Methods......Page 33 Orthogonality of chromatographic modes......Page 34 Compatibility matrix of chromatographic modes......Page 35 Mono-, Sesqui-, Di-, and Triterpenes......Page 37 Iridoids and Secoiridoids......Page 38 Carotenoids......Page 40 Saponins......Page 43 Coumarins......Page 45 Flavonoids and Isoflavonoids......Page 48 Alkaloids......Page 50 Conclusions......Page 52 Abbreviations......Page 54 References......Page 55 Introduction......Page 61 Protein Crystals......Page 62 Obtaining Protein Crystals......Page 64 Principles of Diffraction......Page 67 Fourier Transforms......Page 70 Diffraction as a Fourier Series......Page 72 The Diffraction Experiment in Practice......Page 73 Phasing Methods......Page 77 Isomorphous Replacement......Page 78 Anomalous Dispersion......Page 80 Molecular Replacement......Page 84 The Electron Density Map......Page 85 Modifying the Electron Density Map......Page 86 Interpreting the Electron Density Map......Page 87 Model Building and Refinement......Page 89 Modelling Disorder: Temperature Factor and Occupancy......Page 91 Model Validation......Page 92 An Example of a Crystal Structure Determination......Page 94 References......Page 97 Characterization by Circular Dichroism Spectroscopy......Page 100 OR of Chiral Compounds