ADVANCES IN GENETICS VOLUME IV Edited by M. DEMEREC Carnegie Institution, Cold Spring Harbor, N . Y. Editorial Board G . W. BEADLE WILLIAMC. BOYD TH. DOBZHANSKY L. C. DUNN MERLE T. J E N K I N S JAY L. LUSH A LFRED MIRRKY 11. J. MULLER J . T. PATTERSON M. M. RHOADER 14. .J. STADLER CURT STERN 1951 ACADEMIC PRESS INC., PUBLISHERS N E W YORK, N . Y . COPYRIGHT0 1951 BY ACADEMICPRESS INC. ALL RIGHTS RESERVED NO PART OF THIS BOOK MAY BE REPRODUCED IN ANY FORM BY PHOTOSTAT, MICROFILM, OR ANY OTHER MEANS, WITHOUT WRITTEN PERMISSION FROM T H E PUBLISHERS ACADEMIC PRESS INC. 111 FIFTHAVENUE NEW YORK. NEW YORK 10003 United Kingdom Edition Published by ACADEMIC PRESS INC. (LONDON) Lm. BERKELEY SQUARE HOUSE, LONDON W. 1 First Printing, 1951 Second Printing, 1964 PRINTED IN T H E UNITED STATES O F AMERICA CONTRIBUTORS TO VOLUME I V A. CARVALHO, Instituto Agrm6mico, Campinas, SGo Paulo, Brazil SALOME GLUECKSOHN-WAELSCH, Department of Zoology, Columbia University, New Y m k , New York ERNSTIIADORN,Zoologisch-vergl. amtomisches Ircstitut, University of Zurich, LYwitzerland ALOHAHANNAH,Department of Zoology, University of California, Berkeley, California C. A. RRUG,Instituto Agrolzdmico, Campinas, SGo Paulo, Brazil R. MATTHEY, Laboratoire de Zoologie, Universite' de Lausanne, Lausanne, Switzerland SEIJINNAGAO, Plant Breeding Institute, Hokkaido University, Sapporo, Japan T. R. RICHMOND, Texas AgriculturaJ Experiment Xtatim, Texas Agricultural and Mechanical College System, College Station, Texas, and U . S. Department of Agricultirre S . G. STEPHENS, Department of A g r o w m y , North Carolina State College, Raleigh, North Carolina M. J. D. WHITE,The University of Texas, Austin, Texas Physiological Genetics of the Mouse SALOME GLUECKSOHN-WAELSCH Department of Zoology. Columbia Vniversity. New Pork. New Pork CONTENTS . . . ..................... I Introduction I1 Analysis of the Yellow Lethal. a Classic Case of a Lethal Mutation I11 Analysis of Gene-Determined Pigment Characters 1 Autonomy of Pigmentation a Mutant Spots b Transplantation 2 Histological Studies of Pigmentation in Different Gene Substitutions 3 Biochemical Studies of Pigmentation in Different Genotypes 4 Correlation of Histological and Biochemical Results 5 Tyrosinase System in the Determination of Pigment Pattern I V Analysis of Gene-Determined Abnormalities of the Blood 1 Siderocytic Anemia in Flexed 2 Macrocytic Anemia in Dominant Spotting V Analysis of Mutat.ions Affecting the Skin and Its Derivatives 1 Transplantation Studies in Waved-2 2 Transplantation Studies in Rhino 3 Rhino and Vitamin A 4 Developmental Studies of Crinkled V I Developmental Studies of Mutations Affecting the Urogenital Sy.stem 1 Kidney Development in Myelencephalic Blebs 2 Kidney Development in Danforth’s Short Tail 3 Inductive Relationship between Ureter and Metanephros 4 Urogenital Syndrome V I I Developmental Studies of Mutations Affecting the Central Nervous System and Sensory Organs 1 Hydrocephalus 2 Congenital Hydrocephalus 3 Pseudencephaly 4 X-Ray-Induced Translocations and Pseudencephaly 5 Shaker Short a Central Nervous System b Ear 6 Effect of Kreisler 011 the Central Nervous System and Ear 7 Eyelees 8 Microphthalmus VIII Analysis of Endocrine Disturbances-Pituitary Dwarfism I X Analyeis of Mutations Affecting the Skeleton 1 Skull a.Harelip 1 . . . . . . . . .