Dementia With Lewy Bodies: Clinical, Pathological, And Treatment Issues

In 1923 Friederich Lewy published a monograph containing neurological, psychiatric and neuropathological data on 43 patients with parkinsonism, of whom 21 were demented. Subsequent studies around the world have raised the profile of this form of dementia, suggesting that it may be more common than previously suspected-perhaps the second most common cause of degenerative dementia after Alzheimer's disease. This book, which represents the first authoritative statement about dementia with Lewy bodies (DLB), arises from a workshop held in Newcastle, England, in October 1995, which brought together leading investigators with clinical and research experience of this condition. It includes review articles, case studies and recent research findings from the main centers studying DLB. The aims of the workshop, and of this volume, were to establish clinical diagnostic criteria and pathological protocols for DLB, and to explore evidence indicating that DLB patients may be more responsive to symptomatic therapy. Covering the classification, cognitive manifestations, clinical diagnosis, epidemiology, genetics, neuropathology, neurochemistry and treatment of DLB, this is a landmark publication in clinical neuroscience. It presents new operational criteria for research on DLB, and will interest all those concerned with the problem of dementia in the elderly. DEMENTIA WITH LEWY BODIES DEMENTIA WITH LEWY BODIES Clinical, pathological, and treatment issues Edited by R. H. PERRY Department of Neuropathology, Newcastle General Hospital, Newcastle upon Tyne, UK I. G. McKEITH Institute for the Health of the Elderly, University of Newcastle upon Tyne, Newcastle upon Tyne, UK E. K. PERRY MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK Foreword by Jeffrey L. Cummings CAMBRIDGE UNIVERSITY PRESS PUBLISHED BY THE PRESS SYNDICATE OF THE UNIVERSITY OF CAMBRIDGE The Pitt Building, Trumpington Street, Cambridge CB2 IRP, United Kingdom CAMBRIDGE UNIVERSITY PRESS The Edinburgh Building, Cambridge CB2 2RU, United Kingdom 40 West 20th Street, New York, NY 10011-4211, USA 10 Stamford Road, Oakleigh, Melbourne 3166, Australia © RH Perry, IG McKeith, EK Perry 1996 This book is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published 1996 Printed in the United States of America Typeset in Adobe Garamond Library of Congress Cataloging-in-Publication Data Dementia with Lewy bodies : clinical, pathological, and treatment issues / [edited by] Robert Perry, Ian McKeith, Elaine Perry, p. cm. Includes index. "International Workshop on Dementia with Lewy Bodies held in Newcastle in October 1995"-Acknowledgements. ISBN 0-521-56188-4 (hardback) 1. Lewy body dementia-Congresses. I. Perry, Robert II. McKeith, Ian. III. Perry, Elaine . IV. International Workshop on Dementia with Lewy bodies (1995) : Newcastle upon Tyne, England) [DNLM: 1. Lewy, Friederich Heinrich, 1885-1950. 2. Dementia, Senile—pathology—congresses. 3.