Essentials of
Apoptosis A Guide for Basic and Clinical Research Edited by
Xiao-Ming Yin, MD, PhD Zheng Dong, PhD
Essentials of Apoptosis
Essentials of Apoptosis A Guide for Basic and Clinical Research Edited by
Xiao-Ming Yin, MD, PhD University of Pittsburgh School of Medicine, Pittsburgh, PA and
Zheng Dong, PhD Medical College of Georgia, Augusta, GA
Humana Press
Totowa, New Jersey
© 2003 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. This publication is printed on acid-free paper. ∞ ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. Production Editor: Robin B. Weisberg. Cover illustrations: The phase micrograph shows dying hepatocytes shrinking and rounding up with intensive membrane blebbing and boiling. One fluorescence micrograph shows one healthy hepatocyte (lower right corner) with mitochondrial cytochrome c (red) and one apoptotic cell (upper left corner) with cytochrome c released into the cytosol (red) and with caspase activation (green). The other photo shows dying cells losing mitochondria transmembrane potentials (red) and their nuclei in fragments (blue), as compared to the healthy cells (lower left corner). Cover artwork courtesy of Xiao-Ming Yin and Wen-Xing Ding, Department of Pathology, University of Pittsburgh School of Medicine. Cover design by Patricia F. Cleary. For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail:
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2002027356
Preface
Life and death are topics that no one takes lightly. In the cell, death by apoptosis is just as fundamental as proliferation for the maintena