Advances In Mass Spectrometry, Volume 16: Plenary And Keynote Lectures Of The 16th International Mass Sepctrometry Conference

ADVANCES IN MASS SPECTROMETRY Volume 16 This Page Intentionally Left Blank ADVANCES IN MASS SPECTROMETRY Volume 16 Plenary and Keynote Lectures of the 16th International Mass Spectrometry Conference held in Edinburgh, UK 31 August–5 September 2003 EDITED BY ALISON E. ASHCROFT The School of Biochemistry and Molecular Biology University of Leeds Leeds LS2 9JT, UK GARETH BRENTON Chemistry Department University of Wales Swansea Singleton Park, Swansea SA2 8PP, UK JOHN J. MONAGHAN School of Chemistry University of Edinburgh Edinburgh EH9 3JJ, UK 2004 Amsterdam – Boston – Heidelberg – London – New York – Oxford Paris – San Diego –San Francisco – Singapore – Sydney –Tokyo ELSEVIER B.V. Sara Burgerhartstraat 25 P.O. Box 211, 1000 AE Amsterdam The Netherlands ELSEVIER Inc. 525 B Street, Suite 1900 San Diego, CA 92101-4495 USA ELSEVIER Ltd The Boulevard, Langford Lane Kidlington, Oxford OX5 1GB UK ELSEVIER Ltd 84 Theobalds Road London WC1X 8RR UK © 2004 Elsevier B.V. All rights reserved. This work is protected under copyright by Elsevier B.V., and the following terms and conditions apply to its use: Photocopying Single photocopies of single chapters may be made for personal use as allowed by national copyright laws. Permission of the Publisher and payment of a fee is required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms of document delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use. Permissions may be sought directly from Elsevier’s Rights Department in Oxford, UK: phone (+44) 1865 843830, fax (+44) 1865 853333, e-mail: [email protected] Requests may also be completed on-line via the Elsevier homepage (http://www.elsevier.com/locate/permissions). In the USA, users may clear permissions and make payments through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA; phone: (+1) (978) 7508400, fax: (+1) (978) 7504744, and in the UK through the Copyright Licensing Agency Rapid Clearance Service (CLARCS), 90 Tottenham Court Road, London W1P 0LP, UK; phone: (+44) 20 7631 5555, fax: (+44) 20 7631 5500. Other countries may have a local reprographic rights agency for payments. Derivative Works Tables of contents may be reproduced for internal circulation, but permission of the Publisher is required for