International Review of Cytology encompasses the recent advances in the understanding of structure-function relationships at the molecular level of receptors, transporters, and membrane proteins. Several diverse families of membrane receptors/proteins are discussed with respect to the molecular and cellular biology of their synthesis, assembly, turnover, and function. Included are such receptor superfamilies as G-proteins, immunoglobulins, ligand-gated receptors, interleukins, and tyrosine kinases as well as such transporter/protein families as pumps, ion channels, and bacterial transporters. Each section of each volume also features a "perspectives/commentary" chapter which includes comments on the recent advances and predictions on new directions. Volume 137A highlights the recent advances in bacterial and glucose transporter mechanisms.
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MOLECULAR BIOLOGY OF RECEPTORS AND TRANSPORTERS BACTERIAL AND GLUCOSE TRANSPORTERS VOLUME 1 3 7 A SERIES EDITORS Geoffrey H. Bourne James F. Denielli 1949-1988 1949-1984 Kwang W. Jeon 1967- Department of Zoology The University of Tennessee Knoxvi He, Tennessee Martin Friedlander 1984- Howard Hughes Medical Institute Jules Stein Eye Institute and Department of Physiology UCLA School of Medicine Los Angeles, California ADVISORY EDITORS Aimee Bakken Eve Ida Barak Howard A. Bern Robert A. Bloodgood Dean Bok Stanley Cohen Rene Couteaux Marie A. DiBerardino Donald K. Dougall Charles J. Flickinger Nicholas Gillham Elizabeth D. Hay Mark Hogarth Keith E. Mostov Audrey Muggleton-Harris Andreas Oksche Muriel J. Ord Vladimir R. Pantic M. V. Parthasarathy Lionel I. Rebhun Jean-Paul Revel L. Evans Roth Jozef St. Schell Hiroh Shibaoka Wilfred Stein Ralph M. Steinman M. Tazawa Alexander L. Yudin Guest Edited by Martin Friedlander Howard Hughes Medical Institute Jules Stein Eye Institute and Department of Physiology UCLA School of Medicine Los Angeles, California Michael Mueckler Department of Cell Biology Washington University School of Medicine St. Louis, Missouri MOLECULAR BIOLOGY OF RECEPTORS AND TRANSPORTERS BACTERIAL AND GLUCOSE TRANSPORTERS VOLUME 137A W Academic Press, Inc. Harcourt Brace Jovanovich, Publishers San Diego New York Boston London Sydney Tokyo Toronto This book is printed on acid-free paper. @ Copyright 0 1992 by ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Academic Press, Inc. 1250 Sixth Avenue, San Diego, California 921 01-431 1 United Kingdom Edition published by Academic Press Limited 24-28 Oval Road, London NW1 7DX Library of Congress Catalog Number: 52-5203 InternationalStandard Book Number: 0-12-364537-9 PRINTED IN THE UNITED STATES OF AMERICA 929394959697 EB 9 8 7 6 5 4 3 2 1 Contributors ....................................................................... Forward ........................................................................... Preface ............................................................................ ix xi xiii Bacterial Periplasmic Permeases as Model Systems for the Superfamily of Traffic ATPases Including the Multidrug Resistance Protein and the Cystic Fibrosis Transmembrane Conductance Regulator Giovanna Ferro-Luzzi Ames I. II. Ill. IV. V. Introduction ..................................... Periplasmic Permeases. ......................... Relevance to Eukaryotic Carriers.. . . . . . . . . . . . . . . Structure-Function Analysis of Eukaryotic