E-Book Content
O,O-Diethyl-O-(2-isopropyl-4- methyl-6-pyrimidinyl) phosphorothionate; 0,0-diethyl-O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate; Diazinon, Alfa-tox, Basudin, Diazol, AG 500, Garden Tox, Knox-out, Spectracide, others TOXICOLOGICAL PROFILE FOR DIAZINON Prepared by: Research Triangle Institute Under Contract No. 205-93-0606 Prepared for: U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry August 1996 DIAZINON DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. DIAZINON UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 DIAZINON CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): Alfred Dorsey, D.V.M. ATSDR, Division of Toxicology, Atlanta, GA James Corcoran, Ph.D. Research Triangle Institute, Research Triangle Park, NC THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1. Green Border Review. Green Border review assures consistency with ATSDR policy. 2. Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. DIAZINON PEER REVIEW A peer review panel was assembled for diazinon. The panel consisted of the following members: 1. Dr. Morris Cranmer, Private Consultant, Cranmer & Associates, Little Rock, Arkansas; 2. Dr. Donald Morgan, Private Consultant, Iowa City, Iowa; and 3. Dr. Josef Seifert, Professor of Environmental Biochemistry, University of Hawaii, Honolulu, Hawaii. These experts collectively have knowledge of diazinon's physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(i)(13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. Scientists from the Agency for Toxic Substances and Disease Registry (ATSDR) have reviewed the peer reviewers' comments and determined which comments will be included in the profile. A listing of the peer reviewers' comments not incorporated in the profile, with a brief explanation of the rationale for their exclusion, exists as part of the administrative record for this compound. A list of databases reviewed and a list of unpublished documents cited are also included in the administrative record. The citation of the peer review panel should not be understood to imply its approval of the profile's final content. The responsibility for the content of this profile lies with the ATSDR. DIAZINON xi CONTENTS FOREWORD CONTRIBUTORS PEER REVIEW LIST OF FIGURES LIST OF TABLES 1. PUBLIC HEALTH STATEMENT 1.1 WHAT IS DIAZINON? 1.2 WHAT HAPPENS TO DIAZINON WHEN IT ENTERS THE ENVIRONMENT? 1.3 HOW MIGHT I BE EXPOSED TO DIAZINON? 1.4 HOW CAN DIAZINON ENTER AND LEAVE MY BODY? 1.5 HOW CAN DIAZINON AFFECT MY HEALTH? 1.6 IS THERE A MEDICAL TEST TO DETERMINE WHETHER I HAVE BEEN EXP