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In the first volume of this series, the structures of protein molecules were described, together with computational methods linking sequence data to folded structure and function. The determination of protein structure by nuclear magnetic resonance spectroscopy was also presented. Volume 2 begins by continuing the theme of protein structure with an outline of methods of crystallographic structure determination. Subsequent chapters describe various strucure-related properties of proteins. This book provides a valuable contribution to those new to the field of protein science as well as to those already expert in the field.
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PROTEIN A Comprehensive Treatise Volume 2 • 1999 This Page Intentionally Left Blank PROTEIN A Comprehensive Treatise Editor: GEOFFREY ALLEN London, England VOLUME 2 • 1999 (jEn) J AI P R E S S I N C Stamford, Connecticut Copyright © 1999 by JAI PRESS INC. 100 Prospect Street Stamford, Connecticut 06904 All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any way, or by any means, electronic, mechanical, photocopying, recording, filming, or otherwise without prior permission in writing from the publisher. ISBN: 1-55938-672-x Manufactured in the United States of America CONTENTS List of Contributors Preface Geoffrey Allen Chapter 1 Protein Crystallography Anirhuddha Achari and David K. Stammers Chapter 2 The Chemistry of Protein Functional Groups Gary E. Means, Hao Zhang, and Min Le Chapter 3 Electrostatic Effects in Proteins: Experimental and Computational Approaches Norma M. Allewell, Himanshu Oberoi, Meena Hariharan, and VinceJ. LiCata Chapter 4 The Binding of Ions to Proteins Jenny P. Glusker Chapter 5 Protein Folding Franz X. Schmid Chapter 6 Thermodynamics of Protein Folding and Stability Alan Cooper v vi Chapter 7 Protein Hydrodynamics Stephen E. Harding INDEX CONTENTS 27) 307 LIST OF CONTRIBUTORS Anirhuddha Achari Glaxo Wellcome Medicines Research Centre Stevenage, Herts, England Norma M. Allewell Department of Biochemistry University of Minnesota St. Paul, Minnesota Alan Cooper Chemistry Department Glasgow University Glasgow, Scotland Jenny P. Glusker Institute for Cancer Research The Fox Chase Cancer Center Philadelphia, Pennsylvania Stephen E. Harding School of Biology University oi Nottingham Sutton Bonington, England Meena Department of Biochemistry Hariharan University of Minnesota St. Paul, Minnesota Gary E. Means Department of Biochemistry The Ohio State University Columbus, Ohio Min Le Department of Biochemistry The Ohio State University Columbus, Ohio VinceJ. LiCata Department of Biochemistry University of Minnesota St. Paul, Minnesota vii LIST OF CONTRIBUTORS VIII Himanshu Oberoi Department of Biochemistry University of Minnesota St. Paul, Minnesota Franz X. Schmid Biochemisches Laboratorium Universitat Bayreuth Bayreuth, Germany David K. Stammers Laboratory of Molecular Biophysics University of Oxford Oxford, England Hao Zhang Department of Biochemistry The Ohio State University Columbus, Ohio PREFACE In Volume 1 of this series, the structures of protein molecules were described, together with computational methods linking sequence data to folded structure and function. The determination of protein structure by nuclear magnetic resonance spectroscopy was also presented. The current volume begins by continuing the theme of pr