Lecture Notes in Bioinformatics 4532 Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong Subseries of Lecture Notes in Computer Science Trey Ideker Vineet Bafna (Eds.) Systems Biology and Computational Proteomics Joint RECOMB 2006 Satellite Workshops on Systems Biology and on Computational Proteomics San Diego, CA, USA, December 1-3, 2006 Revised Selected Papers 13 Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Trey Ideker University of California Department of Bioengineering San Diego, CA 92093, USA E-mail:
[email protected] Vineet Bafna University of California Computer Science and Engineering Dept. San Diego, CA 92093, USA E-mail:
[email protected] Library of Congress Control Number: 2007931338 CR Subject Classification (1998): F.2, G.3, E.1, H.2.8, J.3 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13 0302-9743 3-540-73059-1 Springer Berlin Heidelberg New York 978-3-540-73059-0 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2007 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12076215 06/3180 543210 Preface The RECOMB Satellite Conferences on Systems Biology and Computational Proteomics were held December 1–3, 2006, at La Jolla, California. The Systems Biology meeting brought researchers together on various aspects of systems biology, including integration of genome-wide microarray, proteomic, and metabolomic data, inference and comparison of biological networks, and model testing through design of experiments. Specific t