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Fourteen chapters provide a snapshot of some of the recent advances in the application of evolutionary and combinatorial techniques in the development of proteins. After outlining the fundamental principles of the field, papers address such topics as the directed evolution of binding proteins by cell surface display, screening strategies of biocatalyst discovery, directed evolution as a means to create enantioselective enzymes for use in organic chemistry, and applied molecular evolution of enzymes involved in synthesis and repair of DNA.
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safecover (100x141x16M jpeg) Directed Molecular Evolution of Proteins: or How to Improve Enzymes for Biocatalysis. Edited by Susanne Brakmann and Kai Johnsson Copyright ã 2002 Wiley-VCH Verlag GmbH & Co. KGaA ISBNs: 3-527-30423-1 (Hardback); 3-527-60064-7 (Electronic) Directed Molecular Evolution of Proteins Edited by S. Brakmann and K. Johnsson Related Titles from Wiley-VCH Kellner,R.; Lottspeich, F.; Meyer, H. E. Microcharacterization of Proteins 1999 ISBN 3-527-30084-8 Bannwarth,W.; Felder, E.; Mannhold, R.; Kubinyi, H.; Timmermann, H. Combinatorial Chemistry. A Practical Approach 2000 ISBN 3-527-30186-0 Gualtieri,F.; Mannhold, R.; Kubinyi, H.; Timmermann, H. New Trends in Synthetic Medicinal Chemistry 2001 ISBN 3-527-29799-5 Clark,D. E.; Mannhold, R.; Kubinyi, H.; Timmermann, H. Evolutionary Algorithms in Molecular Design 2000 ISBN 3-527-30155-0 Directed Molecular Evolution of Proteins or How to Improve Enzymes for Biocatalysis Edited by Susanne Brakmann and Kai Johnsson The Editor of this volume Dr. Susanne Brakmann AG ¹Angewandte Molekulare Evolutionª Institut fuÈr Spezielle Zoologie UniversitaÈt Leipzig Talstraûe 33 04103 Leipzig, Germany Prof. Dr. K