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Completely rewritten to enhance clarity, this third edition provides engineers with a strong understanding of the field. With the help of an additional co-author, the text presents new information on bioseparations throughout the chapters. A new chapter on mechanical separations covers settling, filtration, and centrifugation, including mechanical separations in biotechnology and cell lysis. Boxes help highlight fundamental equations. Numerous new examples and exercises are integrated throughout as well. In addition, frequent references are made to the software products and simulators that will help engineers find the solutions they need.
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This page intentionally left blank FFIRS 09/16/2010 8:48:25 Page 1 SEPARATION PROCESS PRINCIPLES Chemical and Biochemical Operations THIRD EDITION J. D. Seader Department of Chemical Engineering University of Utah Ernest J. Henley Department of Chemical Engineering University of Houston D. Keith Roper Ralph E. Martin Department of Chemical Engineering University of Arkansas John Wiley & Sons, Inc. FFIRS 09/16/2010 8:48:25 Page 2 Vice President and Executive Publisher: Don Fowley Acquisitions Editor: Jennifer Welter Developmental Editor: Debra Matteson Editorial Assistant: Alexandra Spicehandler Marketing Manager: Christopher Ruel Senior Production Manager: Janis Soo Assistant Production Editor: Annabelle Ang-Bok Designer: RDC Publishing Group Sdn Bhd This book was set in 10/12 Times Roman by Thomson Digital and printed and bound by Courier Westford. The cover was printed by Courier Westford. This book is printed on acid free paper. Founded in 1807, John Wiley & Sons, Inc. has been a valued source of knowledge and understanding for more than 200 years, helping people around the world meet their needs and fulfill their aspirations. Our company is built on a foundation of principles that include responsibility to the communities we serve and where we live and work. In 2008, we launched a Corporate Citizenship Initiative, a global effort to address the environmental, social, economic, and ethical challenges we face in our business. Among the issues we are addressing are carbon impact, paper specifications and procurement, ethical conduct within our business and among our vendors, and community and charitable support. For more information, please visit our website: www.wiley.com/go/citizenship. Copyright # 2011, 2006, 1998 John Wiley & Sons, Inc. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except as permitted under Sections 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc. 222 Rosewood Drive, Danvers, MA 01923, website www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030-5774, (201)748-6011, fax (201)748-6008, website http://www.wiley.com/go/permissions. Evaluation copies are provided to qualified academics and professionals for review purposes only, for use in their courses during the next academic year. These copies are licensed and may not be sold or transferred to a third party. Upon completion of the review period, please return the evaluation copy to Wiley. Return instructions and a free of charge return shipping label are available at www.wiley.com/go/returnlabel. Outside of the United States, please contact your local representative. Library of Congress Cataloging-in-Publication Data Seader, J. D. Separatio