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Cancer Vaccines and Tumor Immunity offers a review of the basic scientific discoveries that have moved forward into clinical trials. Presented in the context of real-world human research and experimentation, these major scientific advances demonstrate how our understanding of immune activation, T-regulatory cells, and autoimmunity will impact cancer vaccine design. The authors also explain how vaccination in the context of bone marrow transplantation will open new avenues for clinical study in the future.
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CANCER VACCINES AND TUMOR IMMUNITY Rimas Orentas, PhD Department of Pediatrics Medical College of Wisconsin James W. Hodge, PhD Laboratory of Tumor Immunology and Biology National Cancer Isntitute Bryon D. Johnson, PhD Department of Pediatrics–Hematology–Oncology Medical College of Wisconsin A JOHN WILEY & SONS, INC., PUBLICATION CANCER VACCINES AND TUMOR IMMUNITY CANCER VACCINES AND TUMOR IMMUNITY Rimas Orentas, PhD Department of Pediatrics Medical College of Wisconsin James W. Hodge, PhD Laboratory of Tumor Immunology and Biology National Cancer Isntitute Bryon D. Johnson, PhD Department of Pediatrics–Hematology–Oncology Medical College of Wisconsin A JOHN WILEY & SONS, INC., PUBLICATION Copyright © 2008 by John Wiley & Sons, Inc. All rights reserved. Published by John Wiley & Sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011, fax (201) 748-6008, or online at http://www.wiley.com/go/permission. Limit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages. For general information on our other products and services or for technical support, please contact our Customer Care Department within the United States at (800) 762-2974, outside the United States at (317) 572-3993 or fax (317) 572-4002. Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic formats. For more information about Wiley products, visit our web site at www.wiley.com. Library of Congress Cataloging-in-Publication Data: Cancer vaccines and tumor immunity / [edited by] Rimas Orentas, James W. Hodge, Bryon D. Johnson. p. ; cm. Includes bibliographical references and index. ISBN 978-0-470-07474-9 (cloth) 1. Cancer vaccines. 2. Tumors—Immunological aspects. I. Orentas, Rimas. II. Hodge, James W. III. Johnson, Bryon D. [DNLM: 1. Neoplasms—therapy. 2. Cance