MEMBRANE PROTEIN TRANSPORT A Multi-Volume Treatise Volume 2 • 1995 This Page Intentionally Left Blank MEMBRANE PROTEIN TRANSPORT A Multi-Volume Treatise Editor: STEPHEN S. ROTHMAN University of California San Francisco, California VOLUME 2 • 1995 JAI PRESS INC. Greenwicli, Connecticut London, England Copyright © 7 995 JAI PRESS INC. 55 Old Post Road, No. 2 Greenwich, Connecticut 06836 JAI PRESS LTD. The Courtyard 28 High Street Hampton Hill, Middlesex TW12 IPD England All rights reserved. No part of this publication may be reproduced, stored on a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, filming, recording, or otherwise, without prior permission in writing from the publisher. ISBN: U55938-983-4 Manufactured in the United States of America CONTENTS LIST OF CONTRIBUTORS THE ROLE OF MOLECULAR CHAPERONES IN TRANSPORT OF PROTEINS ACROSS MEMBRANES Elizabeth A. Craig, B. Diane Gambill, Wolfgang Voos, and Nikolaus Pfanner THE NUCLEAR PORE COMPLEX IN YEAST Paola Grandi and Eduard C. Hurt ATP BINDING CASSETTE TRANSPORTERS IN YEAST: FROM MATING TO MULTIDRUG RESISTANCE Ralf Egner, Yannick Make, Rudy Pandjaitan, Veronika Huter, Andrea Lamprecht, and Karl Kuchler vii 1 29 57 THE APICAL SORTING OF GLYCOSYLPHOSPHATIDYLINOSITOL-LINKED PROTEINS Michael P. Lisanti, ZhaoLan Tang, Philipp E. Scherer, and Massimo Sargiacomo CAVEOLAE: PORTALS FOR TRANSMEMBRANE SIGNALING AND CELLULAR TRANSPORT Michael P. Lisanti, ZhaoLan Tang, and Massimo Sargiacomo NUCLEAR TRANSPORT OF URACIL-RICH SMALL NUCLEAR RIBONUCLEOPROTEIN PARTICLES Elisa Izaurralde, lain W. Mattaj, and David S. Goldfarb 97 111 123 vi CONTENTS PHOSPHORYLATION-MEDIATED REGULATION OF SIGNAL-DEPENDENT NUCLEAR PROTEIN TRANSPORT: THE "CcN MOTIF" David A. Jans 161 MEMBRANE PROTEIN TOPOGENESIS IN ESCHERICHIA COLI Gunnar von Heijne 201 MODEL FOR INTEGRATING P-TYPE ATPases INTO ENDOPLASMIC RETICULUM Randolph Addison andjialing Lin 215 NUCLEAR TRANSPORT AS A FUNCTION OF CELLULAR ACTIVITY Carl M. Feldherr and Debra Akin 237 INDEX 261 LIST OF CONTRIBUTORS Randolph Addison Department of Biochemistry Health Science Center University of Tennessee Memphis, Tennessee Debra Akin Department of Anatomy and Cell Biology College of Medicine University of Florida Gainsville, Florida Elizabeth A. Craig Department of Biomolecular Chemistry University of Wisconsin Madison, Wisconsin Carl M. Feldherr Department of Anatomy and Cell Biology College of Medicine University of Florida Gainsville, Florida B. Diane Cambill Department of Biomolecular Chemistry University of Wisconsin Madison, Wisconsin David S. Goldfarb Department of Biology University of Rochester Rochester, New York Paola Grandi European Molecular Biology Laboratory Heidelberg, Germany RalfEgner Department of Molecular Genetics University and Biocenter of Vienna Vienna, Austria VII VIM LIST OF CONTRIBUTORS Eduard C. Hurt European Molecular Biology Laboratory Heidelberg, Germany Veronika Huter Department of Molecular Genetics LJniversity and Biocenter of Vienna Vienna, Austria Elisa Izaurralde European Molecular Biology Laboratory Heidelberg, Germany<