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Salmonella enterica encompasses a diverse range of bacteria that cause a spectrum of diseases in many hosts. However, advancements in the prevention and treatment of its infections have been hampered by limited research efforts and lack of multidisciplinary approaches. This book covers a diverse range of relevant topics, including epidemiological and clinical aspects, molecular pathogenesis, and immunity to disease and vaccines. The book's up-to-date information on key aspects of salmonellosis in humans and animals, will interest graduate students and researchers, as well as clinicians.
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Salmonella Infections Clinical, Immunological and Molecular Aspects Salmonella enterica encompasses a diverse range of bacteria that cause a spectrum of diseases in many hosts. Advancements in prevention and treatment of S. enterica infections have at times been hampered by compartimentalization of research efforts and lack of multidisciplinary approaches. This book attempts to cover a diverse range of topics related to the biology of S. enterica infections, including epidemiological and clinical aspects, molecular pathogenesis, immunity to disease and vaccines. Salmonella enterica infections are important zoonoses and therefore material on infections of animals and public health issues have also been considered. Each chapter can be read independently, but the full contents of the book will provide the reader with up-to-date knowledge on all the key aspects of salmonellosis in humans and animals. It will therefore be of interest to graduate students and researchers, as well as to clinicians, whose research focuses on this important pathogen. is a senior lecturer in the Department of Veterinary Medicine at the University of Cambridge, where he leads the Bacterial Immunology Group. PIETRO MASTROENI DUNCAN MASKELL is Marks & Spencer Professor of Farm Animal Health, Food Science and Food Safety and Head of the Department of Veterinary Medicine at the University of Cambridge, where he leads the Bacterial Infection Group. CELLULAR MICROBIOLOGY Over the past decade, the rapid development of an array of techniques in the fields of cellular and molecular biology has transformed whole areas of research across the biological sciences. Microbiology has perhaps been influenced most of all. Our understanding of microbial diversity and evolutionary biology and of how pathogenic bacteria and viruses interact with their animal and plant hosts at the molecular level, for example, have been revolutionized. Perhaps the most exciting recent advance in microbiology has been the development of the interface discipline of Cellular Microbiology, a fusion of classic microbiology, microbial molecular biology, and eukaryotic cellular and molecular biology. Cellular Microbiology is revealing how pathogenic bacteria interact with host cells in what is turning out to be a complex evolutionary battle of competing gene products. Molecular and cellular biology are no longer discrete subject areas but vital tools and an integrated part of current microbiological research. As part of this revolution in molecular biology, the genomes of a growing number of pathogenic and model bacteria have been fully sequenced, with immense implications for our future understanding of microorganisms at the molecular level. Advances in Molecular and Cellular Microbiology is a series edited by researchers active in these exciting and rapidly expanding fields. Each volume will focus on a particular aspect of cellular or molecular microbiology and will provide an overview of the area; it will also examine current research. This series will enable graduate students and researchers to keep up with the rapidly diversifying literature in current microbiological research. n ADVANCES IN MOLECULAR AND AMCM Series Edi