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This volume is the first attempt to summarize current knowledge about the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all previous authors attempted to put their findings into a context for translation to the clinical situation, the state of the art does not fully allow this because the field of metastasis is relatively new. Nonetheless, the contents of this volume will be of use to members of the cancer research community and clinicians interested in developing and implementing novel forms of treatment for cancer.
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Cancer Metastasis – Related Genes Cancer Metastasis – Biology and Treatment VOLUME 3 Series Editors Richard J. Ablin, Ph.D., Innapharma, Inc., Park Ridge, NJ, U.S.A. Wen G. Jiang, M.D., University of Wales College of Medicine, Cardiff, U.K. Advisory Editorial Board Harold F. Dvorak, M.D. Phil Gold, M.D., Ph.D. Ian R. Hart, Ph.D. Hiroshi Kobayashi, M.D. Robert E. Mansel, M.S., FRCS. Marc Mareel, M.D., Ph.D. Titles published in this Series are: Volume 1: Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Editors: Wen G. Jiang and Robert E. Mansel. ISBN 0-7923-6395-7 Volume 2: Growth Factors and Receptors in Cancer Metastasis. Editors: Wen G. Jiang, Kunio Matsumoto, and Toshikazu Nakamura. ISBN 0-7923-7141-0 Cancer Metastasis – Related Genes Edited by Danny R. Welch Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Pennsylvania, The United States of America KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN: Print ISBN: 0-306-47821-8 1-4020-0522-9 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print ©2002 Kluwer Academic Publishers Dordrecht All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: and Kluwer's eBookstore at: http://kluweronline.com http://ebooks.kluweronline.com TABLE OF CONTENTS Preface Danny R. Welch vii List of Contributors xi Chapter 1 Metastasis-Suppressor Genes: A Review and Perspective on an Emerging Field Barbara A. Yoshida, Zita Dubauskas, Mitchell H. Sokoloff, Danny R. Welch, Carrie W. Rinker-Schaeffer Chapter 2 The Roles of Map Kinases in Controlling Cancer Metastasis Alessandro Alessandrini 1 35 51 Chapter 3 Tumor Metastasis-associated Human Mta1 Gene: Role in Epithelial Cancer Cell Proliferation and Regulation Garth L. Nicolson, Akihiro Nawa, Yasushi Toh, Shigeki Taniguchi, Katsuhiko Nishimori Chapter 4 Cooperative Integrin Interactions in the Regulation of Tumor Metastasis Peter C. Brooks 65 Chapter 5 Brain Metastasis Associated Genes Dario Marchetti 89 109 Chapter 6 Autocrine Motility Factor and its Receptor as Regulators of Metastasis Yasuharu Onishi, Arayo Haga, Avraham Raz Chapter 7 123 nm23 Metastasis Suppressor Gene Patricia S. Steeg, Taoufik Ouatas, Michael Mair, Susan E. Clare, Melanie T. Hartsough v Chapter 8 Gene Regulation in Melanoma Metastasis Menashe Bar-Eli Chapter 9 Heterochromatin-associated Protein 1, Invasion and Metastasis Dawn A. Kirschmann, Mary J.C. Hendrix 145 169 in Breast Cancer Chapter 10 191 Inhibition of Invasion and Metastasis During Specific Amino Acid Restriction Associated with Metastasis Suppressor and Other Gene Changes Gary G. Meadows, Xiaokang Ge, Hui Zhang, Daniel R. Oros, Ya-Min Fu Chapter 11 Role of BRMS1 in Breast Carcinoma Metastasis Rajeev S. Samant, Lalita R. Shev