E-Book Overview
These Proceedings of the 1st International Peptide Symposium, held in Kyoto, Japan, in December 1997, represent a high point of international cooperation in the field of peptide science. Recently, science and technology in this area have advanced considerably, allowing traditional peptide chemists to expand into areas of peptide science encompassing physics, biology and medicine. Furthermore, improvements in procedures for chemical and bio-syntheses, purification, analysis and related areas, have removed barriers with respect to the size of molecules. These Proceedings include plenary lectures and oral and poster presentations collected from a wide diversity of topics providing a truly comprehensive and up-to-date overview of the field of peptide science. This publication contains essential reference information for researchers active in peptide science.
E-Book Content
PEPTIDE SCIENCE – PRESENT AND FUTURE This page intentionally left blank. PEPTIDE SCIENCE – PRESENT AND FUTURE Proceedings of the 1st International Peptide Symposium Edited by YASUTSUGU SHIMONISHI Osaka University, Japan KLUWER ACADEMIC PUBLISHERS N E W Y O R K , B O S T O N , D O R D R E C H T, LONDON , MOSCOW eBook ISBN 0-306-46864-6 Print ISBN 0-792-35271-8 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: and Kluwer's eBookstore at: http://www.kluweronline.com http://www.ebooks.kluweronline.com Contents xxxv Preface First International Peptide Symposium xxxvii Acknowledgements xxxix Abbreviations xli Plenary lectures 1. 2. From big molecules to smaller ones J.A. Wells, B.C. Cunningham, A. Braisted, S. Atwell, W. DeLano, M. Ultsch, M.A. Starovasnik and A.M. de Vos 1 Directions for solving the remaining problems in the synthesis of large peptides S. Sakakibara 6 General lectures 3. 4. Peptide science: past, present and future D. Brandenburg 15 Quo vadis? Where is peptide chemistry headed? T. Shiba 21 Session A: Peptide mimetics and de novo design 5. 6. 7. 8. Designing peptidomimetic antagonists for peptide receptors: topochemical differences of agonists and antagonists V.J. Hruby, S. Liao, G. Han, G. Bonner, M. Shenderovich, J. Slaninova, F. Porreca, H.I. Yamamura and M.E. Hadley 26 Self-assembling homopolymeric peptide tapes in aqueous solution A. Aggeli, M. Bell, A. Strong, S. Radford and N. Boden 30 Peptides containing nonnatural amino acids with functional side groups M. Sisido 34 Active carbonates of N-protected amino alcohols for synthesis of carbamate pseudopeptides J.B. Halstrøm 39 v vi 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. Contents Convenient one-pot synthesis of cystine-containing peptides from protected peptidyl resins and its application to the synthesis of bifunctional anti-HIV compounds H. Tamamura, T. Ishihara, H. Oyake, A. Otaka and N. Fujii 41 Stereoselective synthesis of two type (E)-alkene dipeptide isosteres from a single substrate of β -aziridinyl- α,β -enoate H. Tamamura, M. Yamashita, H. Muramatsu, T. Ibuka, A. Otaka and N. Fujii 44 Design and synthesis of conformationally constrained dipeptide containin