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While a reliable supply of donated blood is vital in modern medicine, it remains the case that blood transfusion comes with its own problems, such as infectious diseases, immunological adverse reactions, and difficulties with long-term storage and transportation of blood components. With a view to solving these problems, developing a suitable blood substitute has been a major goal for decades. Artificial Oxygen Carrier: Its Front Line is a compilation of reports on the concepts behind artificial oxygen carriers, as well as the new discoveries in the field that were presented during the 13th Keio International Symposium for Life Science and Medicine. This volume describes valuable topics, including artificial red blood cells, modified haemoglobin, perfluorocarbons, and haemoglobin vesicles. It explains cutting-edge developments in artificial oxygen carrier research and will be a valuable resource to all concerned with the field.
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Keio University International Symposia for Life Sciences and Medicine Vol. 12 K. Kobayashi, E. Tsuchida, H. Horinouchi (Eds.) Artificial Oxygen Carrier Its Front Line
K. Kobayashi, E. Tsuchida, H. Horinouchi (Eds.)
Artificial Oxygen Carrier Its Front Line
With 75 Figures, Including 7 in Color
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Koichi Kobayashi, M.D., Ph.D. Chief Professor of Surgery Division of General Thoracic Surgery, Department of Surgery School of Medicine, Keio University 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan Eishun Tsuchida, Ph.D. Professor Emeritus Department of Polymer Chemistry, Waseda University 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan Hirohisa Horinouchi, M.D., Ph.D. Division of General Thoracic Surgery, Department of Surgery School of Medicine, Keio University 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Library of Congress Control Number: 2004111703
ISBN 4-431-22074-7 Springer-Verlag Tokyo Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Tokyo 2005 Printed in Japan Typesetting: SNP Best-set Typesetter Ltd., Hong Kong Printing and binding: Shinano, Inc., Japan Printed on acid-free paper
Foreword
This volume of the Keio University International Symposia for Life Sciences and Medicine contains the proceedings of the 13th symposium held under the sponsorship of the Keio University Medical Science Fund. The fund was established by the generous donation of the late Dr. Mitsunada Sakaguchi. The Keio University International Symposia for Life Sciences and Medicine constitute one of the core activities sponsored by the fund, of which the objective is to contribute to the international community by developing human resources, promoting scientific knowledge, and encouraging mutual exchange. Each year, the Committee of the International Symposia for Life Sciences and Medicine selects the most significant symposium topics from applications received from the Keio medical community. The publication of the proceedings is intended to publicize and distribute the information arising from the l