This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.
Oxidative Stress in Applied Basic Research and Clinical Practice
Editor-in-Chief Donald Armstrong
For other titles published in this series, go to http://www.springer.com/series/8145
Note from the Editor-in-Chief All books in this series illustrate point-of-care testing and critically evaluate the potential of antioxidant supplementation in various medical disorders associated with oxidative stress. Future volumes will be updated as warranted by emerging new technology, or from studies reporting clinical trials. Donald Armstrong Editor-in-Chief
Heinrich Sauer · Ajay M. Shah · Francisco R.M. Laurindo Editors
Studies on Cardiovascular Disorders
Editors Heinrich Sauer Universität Gießen Physiologisches Institut Aulweg 129 35392 Gießen Germany
[email protected] unigiessen.de
Ajay M. Shah King’s College London James Black Centre Coldharbour Lane 125 SE5 9NU London King’s Denmark Hill Campus United Kingdom
[email protected]
Francisco R.M. Laurindo Universidade of São Paulo Fac. Medicina Instituto do Coração (INCOR) Lab. Biologia Molecular Av. Enéas de Carvalho Aguiar 44 05403-000 São Paulo, São Paulo Subsolo Brazil
[email protected]
ISBN 978-1-60761-599-6 e-ISBN 978-1-60761-600-9 DOI 10.1007/978-1-60761-600-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010934121 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013