Tnf Superfamily

MEDICAL Intelligence Unit Medica l i n t e l l i g e n c e unit The chapters in this book, as well as the chapters of all of the five Intelligence Unit series, are available at our website. Biotechnology Intelligence Unit Medical Intelligence Unit Molecular Biology Intelligence Unit Neuroscience Intelligence Unit Tissue Engineering Intelligence Unit Khare INTELLIGENCE UNITS Sanjay Khare MIU TNF Superfamily TNF Superfamily MEDICAL INTELLIGENCE UNIT TNF Superfamily Sanjay Khare Amgen Inc. Thousand Oaks, California, U.S.A. LANDES BIOSCIENCE AUSTIN, TEXAS U.S.A. TNF SUPERFAMILY Medical Intelligence Unit Landes Bioscience Copyright ©2007 Landes Bioscience All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Please address all inquiries to the Publishers: Landes Bioscience, 1002 West Avenue, Second Floor, Austin, Texas 78701 U.S.A. Phone: 512/ 637 6050; Fax: 512/ 637 6079 www.landesbioscience.com ISBN: 978-1-58706-306-0 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library of Congress Cataloging-in-Publication Data TNF superfamily / [edited by] Sanjay Khare. p. ; cm. -- (Medical intellegence unit) Includes bibliographical references. ISBN-13: 978-1-58706-306-0 1. Tumor necrosis factor. I. Khare, Sanjay. II. Series: Medical intelligence unit (Unnumbered : 2003) [DNLM: 1. Tumor Necrosis Factors. QU 55.2 T6265 2007] QR185.8.T84T56 2007 616.07'9--dc22 2007034203 CONTENTS Preface ................................................................................................. xii 1. CD40 and CD154 ................................................................................. 1 Iqbal S. Grewal CD40/CD154 Structural Features and Their Expression ...................... 2 Signalling through CD40 ...................................................................... 3 Regulation of Activity of APC ............................................................... 4 Role of CD40-CD154 Interaction in T Cell Priming ............................ 4 CD40-CD154 and Inflammation ......................................................... 5 CD40-CD154 and Atherosclerosis ........................................................ 6 Role of CD40-CD154 in Autoimmunity .............................................. 6 Role of CD40-CD154 Interactions in Transplantation ......................... 7 CD40-CD154 in Innate Immune Response .......................................... 7 Role of CD40 Ligand in Amyloidosis and Alzheimer’s Disease .............. 8 CD40-CD154 in the Control of Infection ............................................ 9 Role of CD40-CD154 in Host Defense against Virus Infections ......... 10 Role of CD40-CD154 in HIV Infections ............................................ 10 CD40-CD154 Regulate Immune Response at Multiple Levels ............ 11 Potential of CD40-CD154 as a Therapeutic Target ............................ 12 2. Regulation of T Cell Immunity by OX40 and OX40L ......................... 19 Michael Croft, Shahram Salek-Ardakani, Jianxun Song, Takanori