Advances in VIRUS RESEARCH VOLUME 33 ADVISORY BOARD DAVIDBALTIMORE PAULKAESBERG ROBERTM. CHANOCK BERNARD Moss PETERC. DOHERTY ERLING NORRBY BERNARD N. FIELDS AKIRAOYA H. J. GROSS J. J. SKEHEL B. D. HARRISON R. H. SYMONS M. H. V. VAN REGENMORTEL Advances in VIRUS RESEARCH Edited by KARL MARAMOROSCH FREDERICK A. MURPHY Department of Entomology Rutgers University Cook Campus New Brunswick, New Jersey Division of Viral Diseases Centers for Disease Control Atlanta, Georgia AARON J. SHATKIN New Jersey Center for Advanced Biotechnology and Medicine Rutgers-UMDNJ Piscataway, New Jersey VOLUME 33 1987 ACADEMIC PRESS, INC. Harcourt Brace Jovanovich, Publishers Orlando San Diego New York Austin Boston London Sydney Tokyo Toronto BY ACADEMIC PRESS,INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS. ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY. RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. COPYRIGHT 0 1987 ACADEMIC PRESS, INC. Orlando. Florida 32887 United Kingdom Edition published by ACADEMIC PRESS INC. (LONDON) 24-28 Oval Road. London NWI 7DX LTD LIBRARY OF CONGRESS CATALOG C A R D NUMBER 53-11559 ISBN 0-12-039833-8 (alk. paper) PRINTED IN THE UNITED STATES OF AMERICA 87 88 89 90 9 8 7 6 5 4 3 2 I CONTENTS Domains of Virus Glycoproteins MILTONJ . SCHLESINGER AND SONDRA SCHLESINGER I. I1. 111. IV . V. VI . VII . VIII . Introduction ....................................................... Influenza Virus Hemagglutinin ..................................... Alphavirus Glycoproteins .......................................... Vesicular Stomatitis and Rabies Virus Glycoproteins ................. Retrovirus Glycoproteins ........................................... Other Virus Glycoproteins .......................................... Virus Glycoproteins and Polarized Cells ............................. Summary and Perspectives ......................................... References ........................................................ 1 2 8 13 22 28 32 33 35 Flavivirus Replication Strategy E . G. WESTAWAY I. I1. 111. IV . Introduction ....................................................... Structure of the Virion ............................................. Replication ........................................................ Summary and Conclusions ......................................... References ........................................................ 45 46 50 82 84 The Autonomously Replicating Parvoviruses of Vertebrates SUSANF. COTMOREAND PETERTATTERSALL I . Introduction ....................................................... I1. Viral Structure and Organization ................................... 111. Viral Life Cycle ................................................... References ........................................................ 91 96 137 169 Regulation of Translation by Poliovirus NAHUMSONENBERG I . Introduction ....................................................... I1. Cap Binding Proteins of Eukaryotic mRNAs ......................... 111. Involvement of the CBP Complex in the Shutoff of Host mRNA Translation after Poliovirus Infection ............................... IV . Alternative Models to Explain Poliovirus Inhibition of Host Protein Synthesis ......................................................... V . Translational Inhibition by Other Picomaviruses .................... VI . Concluding Remar