Nuclear Receptors As Drug Targets (methods And Principles In Medicinal Chemistry)

Nuclear Receptors as Drug Targets Edited by Eckhard Ottow and Hilmar Weinmann Methods and Principles in Medicinal Chemistry Edited by R. Mannhold, H. Kubinyi, G. Folkers Editorial Board H. Timmerman, J. Vacca, H. van de Waterbeemd, T. Wieland Previous Volumes of this Series: D. Rognan (ed.) W. Jahnke, D. A. Erlanson (eds.) Ligand Design for G Protein-coupled Receptors Fragment-based Approaches in Drug Discovery Vol. 30 Vol. 34 2006 2006 ISBN 978-3-527-31284-9 ISBN 978-3-527-31291-7 D. A. Smith, H. van de Waterbeemd, D. K. Walker J. Hüser (ed.) Pharmacokinetics and Metabolism in Drug Design, 2nd Ed. High-Throughput Screening in Drug Discovery Vol. 35 2006 Vol. 31 ISBN 978-3-527-31283-2 2006 K. Wanner, G. Höfner (eds.) ISBN 978-3-527-31368-6 T. Langer, R. D. Hofmann (eds.) Mass Spectrometry in Medicinal Chemistry Pharmacophores and Pharmacophore Searches Vol. 36 Vol. 32 ISBN 978-3-527-31456-0 2006 R. Mannhold (ed.) ISBN 978-3-527-31250-4 2007 Molecular Drug Properties E. Francotte, W. Lindner (eds.) Vol. 37 Chirality in Drug Research 2008 Vol. 33 ISBN 978-3-527-31755-4 2006 R. J. Vaz, T. Klabunde (eds.) ISBN 978-3-527-31076-0 Antitargets Vol. 38 2008 ISBN 978-3-527-31821-6 Nuclear Receptors as Drug Targets Edited by Eckhard Ottow and Hilmar Weinmann Series Editors Prof. Dr. Raimund Mannhold Molecular Drug Research Group Heinrich-Heine-Universität Universitätsstrasse 1 40225 Düsseldorf Germany [email protected] Prof. Dr. Hugo Kubinyi Donnersbergerstrasse 9 67256 Weisenheim am Sand Germany [email protected] Prof. Dr. Gerd Folkers Collegium Helveticum STW/ETH Zurich 8092 Zurich Switzerland [email protected] All books published by Wiley-VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate. Library of Congress Card No.: applied for British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. Bibliographic information published by the Deutsche Nationalbibliothek Die Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at http://dnb.d-nb.de. # 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Volume Editors Prof. Dr. Eckhard Ottow Bayer Schering Pharma AG Medicinal Chemistry (S106/345) 13342 Berlin Dr. Hilmar Weinmann Bayer Schering Pharma AG Medicinal Chemistry (S106/048A) 13342 Berlin Cover Descipti