Prevention And Treatment Of Age-related Diseases

PREVENTION AND TREATMENT OF AGE-RELATED DISEASES Prevention and Treatment of Age-related Diseases Edited by Suresh I.S. Rattan Danish Centre for Molecular Gerontology, University of Aarhus, Denmark and Moustapha Kassem University Hospital of Odense, Denmark A C.I.P. Catalogue record for this book is available from the Library of Congress. ISBN-10 ISBN-13 ISBN-10 ISBN-13 1-4020-4884-X (HB) 978-1-4020-4884-5 (HB) 1-4020-5058-5 (e-book) 978-1-4020-5058-9 (e-book) Published by Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. www.springer.com Printed on acid-free paper All Rights Reserved © 2006 Springer No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. CONTENTS Preface Suresh I.S. Rattan and Moustapha Kassem 1. Biological Causes of Aging and Age-Related Diseases Suresh I.S. Rattan 2. Immunity, Inflammation and Infections During Aging: The Susceptibility to Infections in Elderly Individuals Miriam Capri, Stefano Salvioli, Federica Sevini, Elisa Cevenini, Michela Pierini, Laura Celani, Laura Bucci, Rita Ostan, Maria Scurti, Daniela Mazza, Daniela Monti and Claudio Franceschi vii 1 15 3. Progress and Development in Parkinson Disease Therapy Carsten R. Bjarkam and Jens C. Sørensen 31 4. Understanding and Treating Alzheimer’s Disease Umesh Kumar, Alexander Roland and Stephen A. Burbidge 49 5. Slowing Down Age-Related Muscle Loss and Sarcopenia P. Noirez and G. Butler-Browne 71 6. Pathophysiology, Prevention and Treatment of Age-Related Osteoporosis in Women Moustapha Kassem and Kim Brixen 87 7. Arthritis and Its Treatment Ashit Syngle 105 8. Recent Developments in the Treatment of Diabetes Type 2 Jan O. Nehlin 133 9. Age-Related Cataract: Management and Prevention Mayank A. Nanavaty, Abhay R. Vasavada and P.D. Gupta 159 10. Skin Aging: Pathogenesis, Prevention and Treatment Mary S. Jung, Kristen M. Kelly and Jerry L. McCullough v 175 vi CONTENTS 11. Aging and Periodontal Disease R. Suresh 193 12. Molecular Diagnosis of Breast Cancer Lise Lotte Hansen 201 13. Prostate Disease in the Aging Male: Prevention, Diagnosis and Treatment of Prostate Cancer Anne R. Simoneau 14. Human Premature Aging Diseases: Molecular Biology to Clinical Diagnosis Dai-Di Gan, Mohammad Hedayati, Tinna Stevnsner and Vilhelm A. Bohr 15. Protein Aggregation in Aging and Age-Related Neurodegenerative Disorders Jeffrey N. Keller and Qunxing Ding 235 271 297 16. Nutritional Deficiency and its Modulation in Old Age Carlos K.B. Ferrari 313 17. Dietary Fats and Age-Related Diseases Kaustuv Bhattacharya and Sure