Gynecologic Cancer: Controversies In Management

The Curtis Center 170 S Independence Mall W 300E Philadelphia, Pennsylvania 19106 or 11830 Westline Industrial Drive St. Louis, Missouri 63146 GYNECOLOGIC CANCER: Controversies in Management Copyright © 2004 by Elsevier Ltd. ISBN 0-443-07142-X All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Distributed in the United Kingdom by Churchill Livingstone, Robert Stevenson House, 1-3 Baxter’s Place, Leith Walk, Edinburgh EH1 3AF, Scotland, and by associated companies, branches, and representatives throughout the world. Notice Gynecology is an ever-changing field. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the licensed prescriber, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the publisher nor the author assumes any liability for any injury and/or damage to persons or property arising from this publication. The Publisher Library of Congress Cataloging-in-Publication Data Gynecologic cancer : controversies in management / [edited by] David M. Gershenson ... [et al.]. p. ; cm. ISBN 0-443-07142-X (alk. paper) 1. Generative organs, Female--Cancer. I. Gershenson, David M. (David Marc), [DNLM: 1. Genital Neoplasms, Female--therapy. WP 145 G9936 2004] RC280.G5G875 2004 616.99′465--dc22 2004045146 Acquisitions Editor: Stephanie Donley Developmental Editor: Alison Nastasi Project Manager: Peter Faber Design Coordinator: Gene Harris Printed in the United States of America. Last digit is the print number: 9 8 7 6 5 4 3 2 1 This book is dedicated to all those women with gynecologic cancers who, in the face of information gaps and therapeutic controversies, have participated in clinical trials. Their hope, faith, courage, and the support of their families have taught us invaluable lessons about the human spirit. Contributors David S. Alberts, MD Regents Professor of Medicine, Pharmacology, and Public Health, University of Arizona School of Medicine; Director, Cancer Prevention and Control, Arizona Cancer Center, Tucson, Arizona Richard R. Barakat, MD Associate Professor of Obstetrics and Gynecology, Cornell University Weill Medical College; Chief, Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York Prevention of Gynecologic Malignancies Prevention of Gynecologic Malignancies Yoland Antill, BMed, FRACP Research Fellow, Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia Karen M. Basen-Engquist, PhD, MPH Associate Professor of Behavioral Science, University of Texas M.D. Anderson Cancer Center, Housto