Current Topics in Membranes, Volume 64
Leukocyte Adhesion
Current Topics in Membranes, Volume 64 Series Editors Dale J. Benos Department of Physiology and Biophysics University of Alabama Birmingham, Alabama
Sidney A. Simon Department of Neurobiology Duke University Medical Centre Durham, North Carolina
Current Topics in Membranes, Volume 64
Leukocyte Adhesion Edited by Klaus Ley Division of Inflammation Biology La Jolla Institute for Allergy and Immunology La Jolla, CA, USA
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Contents Contributors xi Foreword xiii Previous Volumes in Series
SECTION 1 CHAPTER 1
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MEMBRANE COMPOSITION AND PROPERTIES Membrane Tethers Richard E. Waugh
I. II. III. IV. V. VI.
Overview 3 Introduction 4 Tethers Formed from Bilayer Vesicles 6 Tethers Formed from Red Blood Cells 10 Tethers from Neutrophils and Other Cells 16 Implications for Cell Adhesion in the Vasculature 19 VII. Conclusion 20 VIII. Future Challenges 21 References 22
CHAPTER 2
Biomechanics of Leukocyte and Endothelial Cell Surface Jin-Yu Shao
I. II. III. IV. V. VI.
Overview 25 Introduction 26 Surface Protrusion and Compression 28 Flexural Stiffness of Leukocyte Microvilli Membrane Tether Extraction 33 Impact of Surface Protrusion and Tether Extraction on Leukocyte Rolling 39 VII. Concluding Remarks 40 References 41
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Contents
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CHAPTER 3
The Cytoskeleton and Deformability of White Blood Cells Damir B. Khismatullin
I. Overview 47 II. Introduction 48 III. Passive Deformation of the Cell Contributes to Cell Rolling 50 IV.