Current Topics in Membranes, Volume 64 Leukocyte Adhesion Current Topics in Membranes, Volume 64 Series Editors Dale J. Benos Department of Physiology and Biophysics University of Alabama Birmingham, Alabama Sidney A. Simon Department of Neurobiology Duke University Medical Centre Durham, North Carolina Current Topics in Membranes, Volume 64 Leukocyte Adhesion Edited by Klaus Ley Division of Inflammation Biology La Jolla Institute for Allergy and Immunology La Jolla, CA, USA AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD • PARIS • SAN DIEGO SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 30 Corporate Drive, Suite 400, Burlington, MA 01803, USA 525 B Street, Suite 1900, San Diego, CA 92101-4495, USA First edition 2009 Copyright # 2009 Elsevier Inc. All rights reserved No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone: (þ44) (0) 1865 843830; fax: (þ44) (0) 1865 853333, email:
[email protected] Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier material Notice No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made ISBN: 978-0-12-374909-3 ISSN: 1063-5823 For information on all Academic Press publications visit our website at elsevierdirect.com Printed and bound in USA 08 09 10 11 12 10 9 8 7 6 5 4 3 2 1 Contents Contributors xi Foreword xiii Previous Volumes in Series SECTION 1 CHAPTER 1 xvii MEMBRANE COMPOSITION AND PROPERTIES Membrane Tethers Richard E. Waugh I. II. III. IV. V. VI. Overview 3 Introduction 4 Tethers Formed from Bilayer Vesicles 6 Tethers Formed from Red Blood Cells 10 Tethers from Neutrophils and Other Cells 16 Implications for Cell Adhesion in the Vasculature 19 VII. Conclusion 20 VIII. Future Challenges 21 References 22 CHAPTER 2 Biomechanics of Leukocyte and Endothelial Cell Surface Jin-Yu Shao I. II. III. IV. V. VI. Overview 25 Introduction 26 Surface Protrusion and Compression 28 Flexural Stiffness of Leukocyte Microvilli Membrane Tether Extraction 33 Impact of Surface Protrusion and Tether Extraction on Leukocyte Rolling 39 VII. Concluding Remarks 40 References 41 32 v Contents vi CHAPTER 3 The Cytoskeleton and Deformability of White Blood Cells Damir B. Khismatullin I. Overview 47 II. Introduction 48 III. Passive Deformation of the Cell Contributes to Cell Rolling 50 IV.