Principles Of Nutrigenetics And Nutrigenomics: Fundamentals Of Individualized Nutrition

E-Book Overview

Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book.

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E-Book Information

• Year: 2,019

• Pages: 586

• Pages In File: 536

• Language: English

• Topic: 178

• Identifier: 9780128045879,9780128045725

• Org File Size: 30,476,635

• Extension: pdf

• Toc: Principles of Nutrigenetics and Nutrigenomics bksec0_2 Copyright Contributors Editor Biographies Preface Supplementary data Introduction 1. The Nature of Traits, Genes and Variation Glossary Phenotypic Traits Gene, Genome, Genotype, and Phenotype Types of Traits: Discrete Traits and Continuous Traits Mendelian Transmission and Polygenic Inheritance: QTLs and Heritability Key Concepts About Gene Interaction Human Genomic Variation The Landscape of the Human Genome Interindividual Genetic Variation Functional Significance of Genetic Variation Suggested Reading 2. Molecular Biology of Genetic Variants Glossary Human Genome Structure Frequency and Relevance of Genomic Variation Types of Genomic Variation Single Nucleotide Polymorphism Deletions, Insertions, and Repeats Complex Patterns of Genomic Variability Haplotypes Hemizygosity Copy Number Variants References 3. Regulation of Gene Expression Glossary Introduction Interplay Between Chromatin Structure and Transcription Factor-DNA Interactions in the Regulation of Gene Expression Transcription of Protein-Coding Genes: General Aspects Pol II Core Promoters PIC Assembly and Transcription Initiation Subsequent Steps in Transcription Chromatin Remodeling and Remodelers Signals and Mechanisms in Transcription Regulation Control of Gene Expression by Di