Biology - Molecular Biology In Medicinal Chemistry

Molecular Biology in Medicinal Chemistry Edited by Th. Dingermann, D. Steinhilber and G. Folkers Molecular Biology in Medicinal Chemistry. Edited by Th. Dingermann, D. Steinhilber, G. Folkers Copyright 8 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ISBN: 3-527-30431-2 Methods and Principles in Medicinal Chemistry Edited by R. Mannhold, H. Kubinyi, G. Folkers Editorial Board H.-D. H€ oltje, H. Timmerman, J. Vacca, H. van de Waterbeemd, T. Wieland Recently Published Volumes: G. Molema, D. K. F. Meijer (eds.) P. Carloni, F. Alber (eds.) Drug Targeting Quantum Medicinal Chemistry Vol. 12 Vol. 17 2001, ISBN 3-527-29989-0 2003, ISBN 3-527-30456-8 D. Smith, D. Walker, H. van de Waterbeemd H. van de Waterbeemd, H Lennern€ as, P. Artursson (eds.) Pharmacokinetics and Metabolism in Drug Design Drug Bioavailability Vol. 13 2001, ISBN 3-527-30197-6 Vol. 18 2003, ISBN 3-527-30438-X H.-J. B€ ohm, G. Schneider (eds.) T. Lengauer (ed.) Protein-Ligand Interactions Bioinformatics – From Genomes to Drugs Vol. 19 2003, ISBN 3-527-30521-1 Vol. 14 R. E. Babine, S. S. Abdel-Meguid (eds.) 2001, ISBN 3-527-29988-2 J. K. Seydel, M. Wiese Protein Crystallography in Drug Discovery Drug-Membrane Interactions Vol. 20 Vol. 15 2002, ISBN 3-527-30427-4 O. Zerbe (ed.) BioNMR in Drug Research Vol. 16 2002, ISBN 3-527-30465-7 2003, ISBN 3-527-30678-1 Molecular Biology in Medicinal Chemistry Edited by Th. Dingermann, D. Steinhilber and G. Folkers Series Editors: Prof. Dr. Raimund Mannhold Biomedical Research Center Molecular Drug Research Group Heinrich-Heine-Universita¨t Universita¨tsstraße 1 40225 Du¨sseldorf Germany [email protected] Prof. Dr. Hugo Kubinyi BASF AG Ludwigshafen c/o Donnersbergstraße 9 67256 Weisenheim am Sand Germany [email protected] Prof. Dr. Gerd Folkers Department of Applied Biosciences ETH Zu¨rich Winterthurerstr. 190 8057 Zu¨rich Switzerland [email protected] Volume Editors: Prof. Dr. Theodor Dingermann Institute of Pharmaceutical Biology Johann Wolfgang Goethe-University Marie-Curie-Str. 9 60439 Frankfurt Germany [email protected] Prof. Dr. Dieter Steinhilber Institute of Pharmaceutical Chemistry Johann Wolfgang Goethe-University Marie-Curie-Str. 9 60439 Frankfurt Germany [email protected] Prof. Dr. Gerd Folkers Department of Applied Biosciences ETH Zu¨rich Winterthurerstr. 190 8057 Zu¨rich Switzerland [email protected] 9 This book was carefully produced. Nevertheless, authors, editors and publisher do not warrant the information contained therein to be free of errors. Readers are advised to keep in