E-Book Overview
Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery.
This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.
E-Book Information
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Series: Gene and cell therapy series
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Year: 2,017
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Edition: 1
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Pages: 458
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Pages In File: 459
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Language: English
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Identifier: 978-1-4987-1191-3,149871191X
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Org File Size: 30,529,452
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Extension: pdf
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Tags:
Lab-On-A-Chip Devices.
Artificial Organs.
Personalized Medicine.
Printing, Three-Dimensional.
Bioprinting.
Regenerative Medicine
methods.
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Toc: Content: Microfabrication and 3-D bioprinting of organs-on-a-chip -- Three-dimensional cell culture -- Electrochemical sensors for organs-on-a-chip -- Microfluidics -- From big data to predictive analysis from in vitro systems -- Lab-on-a-chip systems for biomedical applications -- From 2D culture to 3D microchip models : trachea, bronchi/bronchiole and lung biomimetic models for disease modeling, drug discovery and personalized medicine -- Liver and liver cancer-on-a-chip -- Heart-on-a-chip -- Skin-on-a-chip -- Tissue engineered kidney models -- Body-on-a-chip -- Integrated multi-organoid dynamics -- Cancer metastasis-on-a-chip -- Breast cancer-on-a-chip -- Disease modeling -- In vivo, in vitro and stem cell technologies to predict human pharmacology and toxicology -- Personalized medicine.